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Fig. 4 | Molecular Autism

Fig. 4

From: The within-subject application of diffusion tensor MRI and CLARITY reveals brain structural changes in Nrxn2 deletion mice

Fig. 4

Tractographic analysis of amygdala-hippocampus and amygdala-orbitofrontal cortex (OFC) connectivity. Amygdala-hippocampal connections are characterised by greater right hemisphere axial diffusivity (AD) in Nrxn2α KO mice (a) but not radial diffusivity (RD) (b). Specific to the BLA, connections to the anterior hippocampus (c) and posterior hippocampus (d) have greater right hemisphere AD. Although the amygdala-OFC connection was similar between the genotypes for AD (e), Nrxn2α KO mice had significantly increased RD (f). *p < 0.05, ***p < 0.001. Error bars represent s.e.m. Wild type n = 6, Nrxn2α KO n = 6

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