Skip to main content
Fig. 3 | Molecular Autism

Fig. 3

From: Haploinsufficiency of autism causative gene Tbr1 impairs olfactory discrimination and neuronal activation of the olfactory system in mice

Fig. 3

MRI reveals that Tbr1+/− mice have a smaller anterior commissure and olfactory bulbs. a MRI brain images showing the reduced size of the olfactory bulbs and anterior commissure of Tbr1+/− mice compared to WT littermates. Upper, coronal section of olfactory bulbs; lower, horizontal section. Pseudocolor indicates regions that are either enlarged or reduced in Tbr1+/− mice. b Quantification of the sizes of brain regions associated with olfaction. Before normalization with whole-brain size, only the posterior part of the anterior commissure is different (red, FDR < 0.1). After normalization with whole-brain size, more regions exhibit differences (indicated in red). * FDR < 0.1; ** FDR < 0.05; *** FDR < 0.01. c Normal lamination and organization of the olfactory system in Tbr1+/− mice, as revealed by Nissl stain. Scale bars 200 μm, (c)

Back to article page