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Table 8 The correlation among PFAS levels in amniotic fluid and receptor transactivity induced by AF

From: Autism spectrum disorders, endocrine disrupting compounds, and heavy metals in amniotic fluid: a case-control study

 

ER-EEQ

EDC-EEQ

AR-AEQ

EDC-AEQ

T3-ThEQ

AhR-TEQ

n

r s

p

n

r s

p

n

r s

p

n

r s

p

n

r s

p

n

r s

p

ASD cases

 PFOS

37

0.522

0.001

30

0.246

0.189

37

− 0.258

0.124

30

− 0.466

0.009

34

0.145

0.398

37

0.097

0.569

 PFOSA

37

0.237

0.158

30

0.199

0.292

37

− 0.391

0.017

30

− 0.163

0.390

36

− 0.038

0.825

37

0.140

0.410

 PFOA

37

0.225

0.180

30

0.317

0.087

37

0.007

0.968

30

− 0.399

0.029

34

0.039

0.822

37

0.125

0.462

 ∑PFSA

37

0.332

0.045

30

0.158

0.403

37

− 0.305

0.066

30

− 0.310

0.095

34

− 0.026

0.882

37

0.100

0.555

 ∑PFCA

37

0.225

0.180

30

0.317

0.087

37

0.007

0.968

30

− 0.399

0.029

34

0.039

0.822

37

0.125

0.462

 ∑PFSA+∑PFCA

37

0.343

0.038

30

0.330

0.075

37

− 0.194

0.249

30

− 0.318

0.087

34

− 0.005

0.978

37

0.138

0.417

Controls

 PFOS

51

0.156

0.276

44

0.273

0.073

51

− 0.082

0.565

46

− 0.010

0.947

48

− 0.004

0.979

51

− 0.065

0.649

 PFOSA

51

0.220

0.121

44

0.356

0.018

51

− 0.160

0.263

46

− 0.108

0.476

49

− 0.221

0.127

51

− 0.273

0.1053

 PFOA

51

0.104

0.469

44

0.097

0.530

51

− 0.002

0.989

46

0.048

0.751

48

0.209

0.150

51

0.148

0.300

 ∑PFSA

51

0.321

0.021

44

0.442

0.003

51

− 0.160

0.263

46

− 0.071

0.641

48

− 0.186

0.202

51

− 0.253

0.074

 ∑PFCA

51

0.100

0.487

44

0.093

0.548

51

− 0.005

0.974

46

0.051

0.736

48

0.203

0.161

51

0.142

0.322

 ∑PFSA+∑PFCA

51

0.332

0.017

44

0.438

0.003

51

− 0.146

0.305

46

− 0.047

0.757

48

− 0.148

0.309

51

− 0.217

0.125

All

 PFOS

88

0.305

0.004

74

0.251

0.031

88

− 0.182

0.090

76

− 0.085

0.465

85

0.18

0.871

88

0.015

0.891

 PFOSA

88

0.224

0.036

74

0.304

0.009

88

− 0.258

0.015

76

− 0.114

0.328

85

− 0.141

0.197

88

− 0.120

0.267

 PFOA

88

0.194

0.070

74

0.212

0.070

88

− 0.031

0.777

76

− 0.127

0.274

82

0.117

0.285

88

0.145

0.178

 ∑PFSA

88

0.342

0.001

74

0.354

0.02

88

− 0.259

0.015

76

− 0.114

0.328

82

− 0.119

0.278

88

− 0.106

0.326

 ∑PFCA

88

0.191

0.074

74

0.210

0.073

88

− 0.033

0.758

76

− 0.123

0.288

82

0.115

0.294

88

0.142

0.187

 ∑PFSA+∑PFCA

88

0.361

0.001

74

0.398

< 0.001

88

− 0.218

0.042

76

− 0.103

0.374

82

− 0.088

0.423

88

− 0.065

0.545

  1. ER-EEQ the combined effect on ER of endogenous estrogen and xeno-estrogens (EDCs) given as estradiol equivalent, EDC-EEQ the integrated estrogenic effect induced only by xeno-estrogens (EDCs) alone given as estradiol equivalent, DHT dihydrotestosterone, AR-AEQ the combined effect on AR of endogenous androgens and xeno-androgens (EDCs) given as androgen equivalent, EDC-AEQ the integrated androgenic effect induced only by xeno-androgens (EDCs) alone given as androgen equivalent, T3 L-3,5,3′-triiiodothyronine, T3-ThEQ the combined proliferation effect (PE) of endogenous thyroid and xeno-thyroid hormone-like compounds (EDCs) given as thyroid equivalent, AhR-TEQ the combined effect on AhR of dioxin-like compounds given as TCDD equivalent, rs, Spearman’s rho correlation coefficient. Italicized values indicate statistically significant (p < 0.05)