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Table 8 The correlation among PFAS levels in amniotic fluid and receptor transactivity induced by AF

From: Autism spectrum disorders, endocrine disrupting compounds, and heavy metals in amniotic fluid: a case-control study

  ER-EEQ EDC-EEQ AR-AEQ EDC-AEQ T3-ThEQ AhR-TEQ
n r s p n r s p n r s p n r s p n r s p n r s p
ASD cases
 PFOS 37 0.522 0.001 30 0.246 0.189 37 − 0.258 0.124 30 − 0.466 0.009 34 0.145 0.398 37 0.097 0.569
 PFOSA 37 0.237 0.158 30 0.199 0.292 37 − 0.391 0.017 30 − 0.163 0.390 36 − 0.038 0.825 37 0.140 0.410
 PFOA 37 0.225 0.180 30 0.317 0.087 37 0.007 0.968 30 − 0.399 0.029 34 0.039 0.822 37 0.125 0.462
 ∑PFSA 37 0.332 0.045 30 0.158 0.403 37 − 0.305 0.066 30 − 0.310 0.095 34 − 0.026 0.882 37 0.100 0.555
 ∑PFCA 37 0.225 0.180 30 0.317 0.087 37 0.007 0.968 30 − 0.399 0.029 34 0.039 0.822 37 0.125 0.462
 ∑PFSA+∑PFCA 37 0.343 0.038 30 0.330 0.075 37 − 0.194 0.249 30 − 0.318 0.087 34 − 0.005 0.978 37 0.138 0.417
Controls
 PFOS 51 0.156 0.276 44 0.273 0.073 51 − 0.082 0.565 46 − 0.010 0.947 48 − 0.004 0.979 51 − 0.065 0.649
 PFOSA 51 0.220 0.121 44 0.356 0.018 51 − 0.160 0.263 46 − 0.108 0.476 49 − 0.221 0.127 51 − 0.273 0.1053
 PFOA 51 0.104 0.469 44 0.097 0.530 51 − 0.002 0.989 46 0.048 0.751 48 0.209 0.150 51 0.148 0.300
 ∑PFSA 51 0.321 0.021 44 0.442 0.003 51 − 0.160 0.263 46 − 0.071 0.641 48 − 0.186 0.202 51 − 0.253 0.074
 ∑PFCA 51 0.100 0.487 44 0.093 0.548 51 − 0.005 0.974 46 0.051 0.736 48 0.203 0.161 51 0.142 0.322
 ∑PFSA+∑PFCA 51 0.332 0.017 44 0.438 0.003 51 − 0.146 0.305 46 − 0.047 0.757 48 − 0.148 0.309 51 − 0.217 0.125
All
 PFOS 88 0.305 0.004 74 0.251 0.031 88 − 0.182 0.090 76 − 0.085 0.465 85 0.18 0.871 88 0.015 0.891
 PFOSA 88 0.224 0.036 74 0.304 0.009 88 − 0.258 0.015 76 − 0.114 0.328 85 − 0.141 0.197 88 − 0.120 0.267
 PFOA 88 0.194 0.070 74 0.212 0.070 88 − 0.031 0.777 76 − 0.127 0.274 82 0.117 0.285 88 0.145 0.178
 ∑PFSA 88 0.342 0.001 74 0.354 0.02 88 − 0.259 0.015 76 − 0.114 0.328 82 − 0.119 0.278 88 − 0.106 0.326
 ∑PFCA 88 0.191 0.074 74 0.210 0.073 88 − 0.033 0.758 76 − 0.123 0.288 82 0.115 0.294 88 0.142 0.187
 ∑PFSA+∑PFCA 88 0.361 0.001 74 0.398 < 0.001 88 − 0.218 0.042 76 − 0.103 0.374 82 − 0.088 0.423 88 − 0.065 0.545
  1. ER-EEQ the combined effect on ER of endogenous estrogen and xeno-estrogens (EDCs) given as estradiol equivalent, EDC-EEQ the integrated estrogenic effect induced only by xeno-estrogens (EDCs) alone given as estradiol equivalent, DHT dihydrotestosterone, AR-AEQ the combined effect on AR of endogenous androgens and xeno-androgens (EDCs) given as androgen equivalent, EDC-AEQ the integrated androgenic effect induced only by xeno-androgens (EDCs) alone given as androgen equivalent, T3 L-3,5,3′-triiiodothyronine, T3-ThEQ the combined proliferation effect (PE) of endogenous thyroid and xeno-thyroid hormone-like compounds (EDCs) given as thyroid equivalent, AhR-TEQ the combined effect on AhR of dioxin-like compounds given as TCDD equivalent, rs, Spearman’s rho correlation coefficient. Italicized values indicate statistically significant (p < 0.05)