Autism spectrum disorders, endocrine disrupting compounds, and heavy metals in amniotic fluid: a case-control study

Table 7 Odds ratio and 95% confidence intervals for ASD according to hormone level and receptor transactivity induced by amniotic fluid

E2 17β-Estradiol, ER-EEQ the combined effect on ER of endogenous estrogen and xeno-estrogens (EDCs) given as estradiol equivalent, EDC-EEQ the integrated estrogenic effect induced only by xeno-estrogens (EDCs) alone given as estradiol equivalent, DHT dihydrotestosterone, AR-AEQ the combined effect on AR of endogenous androgens and xeno-androgens (EDCs) given as androgen equivalent, EDC-AEQ the integrated androgenic effect induced only by xeno-androgens (EDCs) alone given as androgen equivalent, T3 L-3,5,3′-triiiodothyronine, T3-ThEQ the combined proliferation effect (PE) of endogenous thyroid and xeno-thyroid hormone-like compounds (EDCs) given as thyroid equivalent, AhR-TEQ the combined effect on AhR of dioxin-like compounds given as TCDD equivalent, FDR (q_value) false discovery rate. Italicized values indicate statistically significant (p < 0.05 and FDR q_value < 0.25)
^aAdjusted for children’s birth year, children’s sex, mother age at delivery, father age at child birth, birth weight, gestational age at birth, gestational week at sampling, Apgar score, parity, and congenital malformation

ISSN: 2040-2392