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Table 7 Odds ratio and 95% confidence intervals for ASD according to hormone level and receptor transactivity induced by amniotic fluid

From: Autism spectrum disorders, endocrine disrupting compounds, and heavy metals in amniotic fluid: a case-control study

  Crude Adjusteda
n (cases/controls) OR (95% CI) p n (cases/controls) OR (95% CI) p FDR (qvalue)
E2 (pg/mL) 68/128 1.000 (0.999, 1.001) 0.629 65/125 1.000 (0.999, 1.001) 0.669 0.771
Testosterone (pg/mL) 67/130 1.001 (1.000, 1.003) 0.050 64/127 1.002 (1.000, 1.004) 0.050 0.437
Testosterone/E2 66/128 1.257 (0.950, 1.664) 0.110 63/125 1.350 (0.935, 1.949) 0.110 0.437
ER-EEQ (pg E2/mL) 75/135 1.000 (0.999, 1.000) 0.358 71/132 1.000 (0.999, 1.000) 0.222 0.500
EDCs-EEQ (pg E2/mL) 68/128 0.999 (0.998, 1.000) 0.112 65/125 0.999 (0.998, 1.000) 0.089 0.437
AR-AEQ (pg DHT/mL) 75/135 0.995 (0.985, 1.006) 0.389 71/132 0.997 (0.985, 1.010) 0.650 0.771
EDCs-AEQ (pg DHT/mL) 67/130 0.989 (0.976, 1.002) 0.109 64/127 0.989 (0.974, 1.005) 0.169 0.437
AR-AEQ/ER-EEQ 75/135 1.269 (0.104, 15.479) 0.852 71/132 2.176 (0.115, 41.15) 0.604 0.771
EDCs-AEQ/EDCs-EEQ 66/128 1.022 (0.794, 1.552) 0.423 63/125 1.032 (0.974, 1.092) 0.285 0.662
T3-ThEQ (ng T3/mL) 74/133 1.094 (0.874, 1.369) 0.434 71/130 1.036 (0.806, 1.332) 0.784 0.822
AhR-TEQ (pgTCDD/mL) 37/51 0.786 (0.238, 2.589) 0.692 36/50 0.792 (0.192, 3.270) 0.747 0.822
  1. E2 17β-Estradiol, ER-EEQ the combined effect on ER of endogenous estrogen and xeno-estrogens (EDCs) given as estradiol equivalent, EDC-EEQ the integrated estrogenic effect induced only by xeno-estrogens (EDCs) alone given as estradiol equivalent, DHT dihydrotestosterone, AR-AEQ the combined effect on AR of endogenous androgens and xeno-androgens (EDCs) given as androgen equivalent, EDC-AEQ the integrated androgenic effect induced only by xeno-androgens (EDCs) alone given as androgen equivalent, T3 L-3,5,3′-triiiodothyronine, T3-ThEQ the combined proliferation effect (PE) of endogenous thyroid and xeno-thyroid hormone-like compounds (EDCs) given as thyroid equivalent, AhR-TEQ the combined effect on AhR of dioxin-like compounds given as TCDD equivalent, FDR (qvalue) false discovery rate. Italicized values indicate statistically significant (p < 0.05 and FDR qvalue < 0.25)
  2. aAdjusted for children’s birth year, children’s sex, mother age at delivery, father age at child birth, birth weight, gestational age at birth, gestational week at sampling, Apgar score, parity, and congenital malformation