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Table 4 Levels of hormones and receptor transactivities in amniotic fluid

From: Autism spectrum disorders, endocrine disrupting compounds, and heavy metals in amniotic fluid: a case-control study

Parameter ASD case Control   
n Median Min-Max N Median Min-Max p FDR (qvalue)
E2 (pg/mL) 68 287.4 78.72–2778 128 311.9 55.02–1005 0.337 0.704
Testosterone (pg/mL) 67 383.6 47.30–1393 130 366.3 80.47–1090 0.173 0.638
Testosterone/E2 ratio 66 1.49 0.21–7.41 128 1.25 0.14–4.310 0.222 0.666
ER-EEQ (pg E2/mL) 75 470.9 204.1–1308 135 545.8 149.0–1308 0.329 0.704
EDC-EEQ (pg E2/mL) 68 168.5 0.28–1226 128 214.4 2.72–1165 0.162 0.638
AR-AEQ (pg DHT/mL) 75 62.60 23.90–137.3 135 62.50 16.90–290.4 0.910 0.910
EDC-AEQ (pg DHT/mL) 67 22.56 1.000–100.4 130 28.45 1.34–274.0 0.167 0.638
AR-AEQ/ER-EEQ 75 0.13 0.02–0.48 135 0.11 0.02–0.98 0.343 0.704
EDC-AEQ/EDCs-EEQ 61 0.18 0.01–59.10 117 0.086 0.003–26.21 0.515 0.764
T3-ThEQ (ng T3/mL) 74 2.36 0.10–17.14 133 2.41 0–6.60 0.594 0.764
AhR-TEQ (pg TCDD/mL) 37 0.24 0–1.310 51 0.15 0–2.10 0.907 0.910
  1. E2 17β-estradiol, ER-EEQ the combined effect on ER of endogenous estrogen and xeno-estrogens (EDCs) given as estradiol equivalent, EDCs-EEQ the integrated estrogenic effect induced only by xeno-estrogens (EDCs) alone given as estradiol equivalent, DHT dihydrotestosterone, AR-AEQ the combined effect on AR of endogenous androgens and xeno-androgens (EDCs) given as androgen equivalent, EDC-AEQ the integrated androgenic effect induced only by xeno-androgens (EDCs) alone given as androgen equivalent, T3 L-3,5,3′-triiiodothyronine, T3-ThEQ the combined proliferation effect (PE) of endogenous thyroid and xeno-thyroid hormone-like compounds (EDCs) given as thyroid equivalent, AhR-TEQ the combined effect on AhR of dioxin-like compounds given as TCDD equivalent, FDR (qvalue) false discovery rate. See the “Methods” section and Table 1 for the different calculations. The difference between cases and controls was compared using non-parametric Mann-Whitney test