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Fig. 1 | Molecular Autism

Fig. 1

From: Modeling the quantitative nature of neurodevelopmental disorders using Collaborative Cross mice

Fig. 1

Genome structures across CC lines in this study. a CC lines used in this study were created from independent three-round intercrosses of eight parental founder strains, five of which are classical laboratory strains (C57BL/6J, A/J, 129S1/SvImJ, NOD/ShiLtJ, and NZO/HlLtJ) and three of which are wild-derived inbred strains (CAST/EiJ, PWK/PhJ, and WSB/EiJ). The resulting F1 mice were iteratively inbred and constitute a population of RI lines that are considered fully inbred at generation F20+. b Example of a genome reconstruction of a CC line, as a mosaic of the eight CC founder strains. Intervals of ambiguity are either caused by remaining heterozygosity or are regions where the founder strains have identical haplotypes. c Overall founder strain contributions in CC lines used for genetic analysis in this study, indicating lower abundance of CAST/EiJ, PWK/PhJ founder haplotypes. d Genome-wide founder strain contributions indicate absence of PWK/PhJ founder haplotypes at three genomic intervals, on chromosomes 2 and 8

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