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Table 3 The microbial pathways significantly impacted by VPA

From: The valproic acid rat model of autism presents with gut bacterial dysbiosis similar to that in human autism

Pathways

Control

VPA

LDA score

P value

ABC transporters

3.29 ± 0.39

3.04 ± 0.24

3.0834

0.0486

Amino acid-related enzymes

1.41 ± 0.01

1.43 ± 0.02

2.0357

0.0039

Bacterial chemotaxis

0.57 ± 0.12

0.47 ± 0.07

2.6664

0.0346

Bacterial motility proteins

1.23 ± 0.27

1.01 ± 0.15

3.0238

0.0411

Bacterial secretion system

0.48 ± 0.02

0.50 ± 0.03

2.1010

0.0167

Carbon fixation pathways in prokaryotes

0.95 ± 0.09

1.03 ± 0.07

2.5883

0.0201

Chaperones and folding catalysts

0.96 ± 0.06

1.01 ± 0.04

2.3375

0.0411

Chromosome

1.51 ± 0.03

1.53 ± 0.02

2.1418

0.0137

Citrate cycle

0.54 ± 0.08

0.62 ± 0.07

2.5479

0.0167

DNA repair and recombination proteins

2.68 ± 0.06

2.75 ± 0.05

2.5379

0.0167

DNA replication

0.62 ± 0.02

0.64 ± 0.02

2.0466

0.0112

DNA replication proteins

1.17 ± 0.03

1.20 ± 0.03

2.2293

0.0346

Flagellar assembly

0.61 ± 0.15

0.48 ± 0.09

2.7850

0.0486

Glycine, serine and threonine metabolism

0.80 ± 0.02

0.82 ± 0.02

2.0011

0.0290

Histidine metabolism

0.63 ± 0.04

0.66 ± 0.02

2.1867

0.0242

Homologous recombination

0.89 ± 0.03

0.93 ± 0.02

2.2693

0.0112

Lipid biosynthesis proteins

0.59 ± 0.03

0.61 ± 0.02

2.0892

0.0486

Oxidative phosphorylation

1.01 ± 0.08

1.08 ± 0.08

2.5044

0.0411

Peptidases

1.90 ± 0.04

1.93 ± 0.03

2.1605

0.0486

Porphyrin and chlorophyll metabolism

0.95 ± 0.04

0.89 ± 0.05

2.4393

0.0201

Protein export

0.55 ± 0.02

0.57 ± 0.02

2.1048

0.0167

Protein kinases

0.34 ± 0.03

0.31 ± 0.02

2.1524

0.0242

Pyrimidine metabolism

1.79 ± 0.03

1.82 ± 0.02

2.2223

0.0242

Riboflavin metabolism

0.19 ± 0.03

0.21 ± 0.02

2.0135

0.0486

Ribosome

2.13 ± 0.07

2.21 ± 0.07

2.6423

0.0167

Terpenoid backbone biosynthesis

0.51 ± 0.02

0.53 ± 0.02

2.0739

0.0201

Transporters

7.52 ± 1.02

6.79 ± 0.66

3.5543

0.0290

Two-component system

1.59 ± 0.13

1.49 ± 0.06

2.6900

0.0290

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Molecular Autism

ISSN: 2040-2392