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Table 3 The microbial pathways significantly impacted by VPA

From: The valproic acid rat model of autism presents with gut bacterial dysbiosis similar to that in human autism

Pathways Control VPA LDA score P value
ABC transporters 3.29 ± 0.39 3.04 ± 0.24 3.0834 0.0486
Amino acid-related enzymes 1.41 ± 0.01 1.43 ± 0.02 2.0357 0.0039
Bacterial chemotaxis 0.57 ± 0.12 0.47 ± 0.07 2.6664 0.0346
Bacterial motility proteins 1.23 ± 0.27 1.01 ± 0.15 3.0238 0.0411
Bacterial secretion system 0.48 ± 0.02 0.50 ± 0.03 2.1010 0.0167
Carbon fixation pathways in prokaryotes 0.95 ± 0.09 1.03 ± 0.07 2.5883 0.0201
Chaperones and folding catalysts 0.96 ± 0.06 1.01 ± 0.04 2.3375 0.0411
Chromosome 1.51 ± 0.03 1.53 ± 0.02 2.1418 0.0137
Citrate cycle 0.54 ± 0.08 0.62 ± 0.07 2.5479 0.0167
DNA repair and recombination proteins 2.68 ± 0.06 2.75 ± 0.05 2.5379 0.0167
DNA replication 0.62 ± 0.02 0.64 ± 0.02 2.0466 0.0112
DNA replication proteins 1.17 ± 0.03 1.20 ± 0.03 2.2293 0.0346
Flagellar assembly 0.61 ± 0.15 0.48 ± 0.09 2.7850 0.0486
Glycine, serine and threonine metabolism 0.80 ± 0.02 0.82 ± 0.02 2.0011 0.0290
Histidine metabolism 0.63 ± 0.04 0.66 ± 0.02 2.1867 0.0242
Homologous recombination 0.89 ± 0.03 0.93 ± 0.02 2.2693 0.0112
Lipid biosynthesis proteins 0.59 ± 0.03 0.61 ± 0.02 2.0892 0.0486
Oxidative phosphorylation 1.01 ± 0.08 1.08 ± 0.08 2.5044 0.0411
Peptidases 1.90 ± 0.04 1.93 ± 0.03 2.1605 0.0486
Porphyrin and chlorophyll metabolism 0.95 ± 0.04 0.89 ± 0.05 2.4393 0.0201
Protein export 0.55 ± 0.02 0.57 ± 0.02 2.1048 0.0167
Protein kinases 0.34 ± 0.03 0.31 ± 0.02 2.1524 0.0242
Pyrimidine metabolism 1.79 ± 0.03 1.82 ± 0.02 2.2223 0.0242
Riboflavin metabolism 0.19 ± 0.03 0.21 ± 0.02 2.0135 0.0486
Ribosome 2.13 ± 0.07 2.21 ± 0.07 2.6423 0.0167
Terpenoid backbone biosynthesis 0.51 ± 0.02 0.53 ± 0.02 2.0739 0.0201
Transporters 7.52 ± 1.02 6.79 ± 0.66 3.5543 0.0290
Two-component system 1.59 ± 0.13 1.49 ± 0.06 2.6900 0.0290
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