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Fig. 2 | Molecular Autism

Fig. 2

From: Inherited and multiple de novo mutations in autism/developmental delay risk genes suggest a multifactorial model

Fig. 2

Multiple-hit model for ASD. a Ten families and corresponding double-hit DNMs in the ACGC, SSC and ASC cohorts are shown. Dagger symbol indicates the genes listed as autism risk genes in SFARI; number sign indicates the variants presented in ExAC database. b The logistic histogram plot shows that both males and females have a higher probability of being affected with an increase in the number of DNMs even after correcting for paternal age effect. Females show a higher odds ratio (OR) than males for this additional DNM effect. c The plot shows the distribution of OR and the corresponding 95% CI of regression models, which predict affected status and different phenotype severity by DNM numbers

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