Fig. 6

Signaling pathway associated with gene expression changes in Sert HZ and KO mice. Diagram of signal transduction pathway associated with genotype and the tryptophan-free diet in Sert HZ and KO mice. Green, “CREB1, Elk-1, TAL1, ARIX, p27KIP1-hz2” pathway that contains genes that are affected by tryptophan deficiency in Sert HZ mice. Purple, “CREB1, Elk-1, B4GT1, PIP, beta-casein-KO” pathway that contains genes that are affected by tryptophan deficiency in Sert KO mice. Orange, genes common to the two pathways. Genes that were included in our data are underlined (Sert HZ mice: 41 genes; Sert KO mice: 14 genes). The cyan arrows indicate canonical pathways, as recorded by MetaCore. The arrows of each color show the following in the corresponding protein; green, activation; red, inhibition; gray, unspecified