Skip to main content

Table 2 Clusters of significant reductions in GWC and WMI in ASD relative to controls

From: The effect of age on vertex-based measures of the grey-white matter tissue contrast in autism spectrum disorder

  Cluster Region labels Side BA Vertices t max p Age (age2)-by-group interactions
GWC 1 Rostral middle frontal gyrus, superior frontal gyrus, precentral gyrus R 10 24,950 − 3.96 3.17 × 10−6 Age (age2)
  2 Inferior parietal cortex, lateral occipital cortex, superior parietal cortex R 39 20,502 − 4.10 3.17 × 10−6 Age (age2)
  3 Postcentral gyrus, superior parietal cortex, supramarginal gyrus R 1/2 6528 − 4.22 3.49 × 10−5 Age (age2)
  4 Supramarginal gyrus, postcentral gyrus, inferior parietal cortex L 40 4828 − 3.84 .00026 Age
  5 Caudal middle frontal gyrus, superior frontal gyrus, rostral middle frontal gyrus L 6 5778 − 3.78 .00046
  6 Rostral middle frontal gyrus, superior frontal gyrus, lateral orbital frontal cortex L 10 5243 − 3.18 .0036
  7 Precuneus cortex, paracentral lobule R 7 3448 − 3.14 .037
WMI 1 Inferior parietal cortex, precuneus cortex, superior parietal cortex R 39 7320 − 3.77 2.27 × 10−6 Age (age2)
  2 Rostral middle frontal gyrus, caudal middle frontal gyrus, pars orbitalis R 9 5219 − 3.48 2.95 × 10−5 Age (age2)
  3 Supramarginal gyrus, inferior parietal cortex, superior temporal gyrus L 40 7096 − 3.75 .0003 Age (age2)
  4 Lateral occipital cortex, inferior temporal gyrus, lingual gyrus L 37 5296 − 3.91 .0005 Age (age2)
  5 Precuneus cortex, isthmus-cingulate cortex L 7 1656 − 3.82 .0018 Age
  6 Lateral orbital frontal cortex R 47 1052 − 4.25 .022
  7 Lateral occipital cortex, inferior temporal cortex, middle temporal gyrus R 19 2907 − 3.07 .04
  8 Fusiform gyrus R 37 1568 − 3.27 .048
  1. Note. GWC, Grey-white matter contrast; WMI, white matter intensity; BA, approximate Brodmann area at tmax within cluster; L, left; R, right; tmax, test statistic within cluster; p, cluster-corrected p value. Vertices: the number of vertices within the cluster; age/age2 indicates existence of significant age-by-group interaction for linear and/or quadratic terms. For each cluster, the three most significant regions are reported