Fig. 8

Effect of levodopa treatment on Ube3a^tm1Alb mice in F1 hybrid 129S2-C57BL/6J background. a Timeline representing levodopa treatment and behavioral phenotyping of Ube3a^m−/p+ mice. b–f Effect of levodopa on the behavioral test battery. Wild-type and Ube3a^m−/p+ (Ube3a^tm1Alb) vehicle-treated mice: n = 15, 15 (WT vehicle = 8 females, 7 males; Ube3a^m−/p+ vehicle = 7 females, 8 males), levodopa-treated wild-type and Ube3a^m−/p+ (Ube3a^tm1Alb) mice: n = 15, 15 mice (WT levodopa = 8 females, 7 males; Ube3a^m−/p+ levodopa = 6 females, 9 males). A multivariate repeated ANOVA or a two-way ANOVA was used for statistical comparison in behavioral phenotypes. ***significant effect of genotype p < 0.001. No effect of genotype was observed in the open field test, since levodopa-treated wild-type mice were similar to Ube3a mice. In none of the tests, we observed an interaction of genotype and treatment