Fig. 6

Audiogenic seizure susceptibility of Ube3a^m−/p+ and Ube3a^mE113X/p+ mice in the 129S2/SvPasCrl background. a Audiogenic seizure susceptibility of WT and Ube3a^m−/p+ mice (n = 45, 114). b Effect of sex on seizure susceptibility in wild-type and Ube3a^m−/p+ mice (females n = 24, 62; males n = 21, 52). c Seizure susceptibility in wild-type and Ube3a^mE113X/p+ mice (n = 4, 8) (WT = 3 females, 1 males; Ube3a^mE113X/p+ = 1 females, 7 males). d Effect of increasing doses of levetiracetam on epilepsy susceptibility of Ube3a^m−/p+ mice (0 mg/kg, n = 12; 0.5 mg/kg, n = 6; 1 mg/kg, n = 6; 2 mg/kg, n = 30; 5 mg/kg, n = 30; 15 mg/kg, n = 30). Fisher’s exact test was used for statistical comparison. ***p < 0.001 for genotype significance