Fig. 4

Behavioral testing of Ube3a^mE113X/p+ (Ube3a^tm2Yelg) mice in the F1 hybrid 129S2-C57BL/6J and the C57BL/6J background. a, b Accelerating rotarod in WT and Ube3a^mE113X/p+ mice in F1 hybrid 129S2-C57BL/6J and C57BL/6J background. c, d Nest building test in WT and Ube3a^mE113X/p+ mice in F1 hybrid 129S2-C57BL/6J and C57BL/6J background. e–g Open field, marble burying, and forced swim tests in WT and Ube3a^mE113X/p+ mice in F1 hybrid 129S2-C57BL/6J and C57BL/6J background. For all behavioral tests, we used a single cohort of 10 wild-type (1 female, 9 males) and 10 Ube3a^mE113X/p+ mice (6 females, 4 males) in F1 hybrid 129S2-C57BL/6J, and 15 wild-type (11 females, 4 males) and 16 Ube3a^mE113X/p+ (Ube3a^tm2Yelg) (13 females, 4 males) mice in C57BL/6J background. All data represent mean ± SEM. A repeated measures ANOVA or T test was used for statistical comparison of genotypes, as described in the legend of Fig. 1. Significant effects of genotype are indicated as *p < 0.05, **p < 0.01, and ***p < 0.001