Fig. 1

Behavioral testing of Ube3a^tm1Alb mice in F1 hybrid 129S2-C57BL/6J background. For each behavioral paradigm, the pooled (raw) data of all experiments is presented on the left panel, whereas the Forrest plots in the middle panel show the normalized data of the individual experiments (in which the data of each experiment is normalized against wild type; represented by a dashed line), as well as the 95% confidence interval. The picture on the right panel shows the behavioral set-up used for our experiments. For the marble burying test and nest building test, the picture shows the onset and finish of a behavioral experiment. a Accelerating rotarod in wild-type (WT) and Ube3a^m−/p+ mice (n = 120, 111). b Open field test in WT and Ube3a^m−/p+ mice (n = 113, 106). c Marble burying test in WT and Ube3a^m−/p+ mice (n = 120, 111). d Nest building test in WT and Ube3a^m−/p+ mice (n = 94, 86). e Forced swim test in WT and Ube3a^m−/p+ mice (n = 120, 111). All data represent mean ± SEM. A repeated measures ANOVA or T test was used for statistical comparison of the non-normalized data. All tests show a significance effect of genotype (***p < 0.001)