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Table 1 Animal models used in this study

From: Clustering the autisms using glutamate synapse protein interaction networks from cortical and hippocampal tissue of seven mouse models

Strain Source and background First citation Behavioral phenotype Synaptic proteins Electrophysiology
Shank3B−/− Jax #017688
[27] Abnormal social behavior; excessive grooming leading to self-injury. Reduced PSD levels of GluR2, NR2A/2B, Homer. In striatum: reduced mEPSP frequency and amplitude; reduced population spike amplitude.
Shank3Δex4–9+/− Jax #017890
[28] Less social sniffing, fewer vocalizations in males exposed to females. Reduced GluR1 immunofluorescent puncta in hippocampus. In hippocampus: reduced mEPSP amplitude but increased frequency. AMPAR-dependent deficit in population spike amplitude. Impaired LTP, normal LTD.
Ube3a2xTG Jax #017482
[34] Abnormal social behavior, fewer ultrasonic vocalizations in adult animals, increased repetitive grooming Reduced ARC levels. In whisker barrel cortex: reduced mEPSP frequency and amplitude; reduced evoked EPSC amplitude.
Cntnap2-/- Jax #017482
[46]; in ASD context [64] Abnormal social behavior, fewer pup ultrasonic vocalizations, increased repetitive grooming   Somatosensory cortex: reduced population synchronization by Ca2+ imaging.
TSC2+/− Jax #004686
[65] Abnormal social behavior [63], impaired hippocampal-dependent memory [37]. Abnormal pup vocalizations [66] Hippocampus: increased mGluR5 [67]. Hippocampus: enhanced LTP [37], reduced LTD in juveniles, abnormal but present LTD in adults [67].
FMR−/y Jax #003025
C57BL/6 J
[68] Abnormal social behavior, increased repetitive behaviors, impaired memory; reviewed in [69]. Less mGluR5 in forebrain PSD preps; normal levels of other GluRs; normal levels of all receptors in total membrane lysates. [70]. Hippocampus: enhanced, abnormal LTD; LTP reported impaired or normal (reviewed by [69]). Cortex: normal LTP at 2 months, abnormal at 12 months [71].
VPA Generated by M. Fahnestock, McMaster U.
[72] (established model); [73] (tested behavior) Reduced social interaction, increased repetitive/stereotyped behaviors [73], reduced vocalizations [74], Cortex of 2-week-old rats: increased NR2A/B, [35]; adult rats: reduced PSD95 [52]. Cortical pyramidal neurons: enhanced NMDAR-mediated currents, enhanced LTP [35].