TY - STD TI - Dagli AI, Mueller J, Williams CA. Angelman syndrome. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, LJH B, Mefford HC, Stephens K, Amemiya A, Ledbetter N, editors. GeneReviews(R). Seattle (WA):University of Washington; 1993. ID - ref1 ER - TY - JOUR AU - Clayton-Smith, J. PY - 2003 DA - 2003// TI - Angelman syndrome: a review of the clinical and genetic aspects JO - J Med Genet VL - 40 UR - https://doi.org/10.1136/jmg.40.2.87 DO - 10.1136/jmg.40.2.87 ID - Clayton-Smith2003 ER - TY - JOUR AU - Dan, B. PY - 2009 DA - 2009// TI - Angelman syndrome: current understanding and research prospects JO - Epilepsia VL - 50 UR - https://doi.org/10.1111/j.1528-1167.2009.02311.x DO - 10.1111/j.1528-1167.2009.02311.x ID - Dan2009 ER - TY - JOUR AU - Williams, C. A. PY - 2005 DA - 2005// TI - Neurological aspects of the Angelman syndrome JO - Brain Dev VL - 27 UR - https://doi.org/10.1016/j.braindev.2003.09.014 DO - 10.1016/j.braindev.2003.09.014 ID - Williams2005 ER - TY - JOUR AU - Mabb, A. M. AU - Judson, M. C. AU - Zylka, M. J. AU - Philpot, B. D. PY - 2011 DA - 2011// TI - Angelman syndrome: insights into genomic imprinting and neurodevelopmental phenotypes JO - Trends Neurosci VL - 34 UR - https://doi.org/10.1016/j.tins.2011.04.001 DO - 10.1016/j.tins.2011.04.001 ID - Mabb2011 ER - TY - JOUR AU - Steffenburg, S. AU - Gillberg, C. L. AU - Steffenburg, U. AU - Kyllerman, M. PY - 1996 DA - 1996// TI - Autism in Angelman syndrome: a population-based study JO - Pediatr Neurol VL - 14 UR - https://doi.org/10.1016/0887-8994(96)00011-2 DO - 10.1016/0887-8994(96)00011-2 ID - Steffenburg1996 ER - TY - STD TI - Dan B. Behavior and neuropsychiatric manifestations in Angelman syndrome. Neuropsychiatr Dis Treat. 2008;4;577. ID - ref7 ER - TY - JOUR AU - Vu, T. H. AU - Hoffman, A. R. PY - 1997 DA - 1997// TI - Imprinting of the Angelman syndrome gene, UBE3A, is restricted to brain JO - Nat Genet VL - 17 UR - https://doi.org/10.1038/ng0997-12 DO - 10.1038/ng0997-12 ID - Vu1997 ER - TY - JOUR AU - Huang, H. S. AU - Allen, J. A. AU - Mabb, A. M. AU - King, I. F. AU - Miriyala, J. AU - Taylor-Blake, B. AU - Sciaky, N. AU - Dutton, J. W. AU - Lee, H. M. AU - Chen, X. PY - 2011 DA - 2011// TI - Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons JO - Nature VL - 481 UR - https://doi.org/10.1038/nature10726 DO - 10.1038/nature10726 ID - Huang2011 ER - TY - JOUR AU - Pommier, Y. AU - Cushman, M. PY - 2009 DA - 2009// TI - The indenoisoquinoline noncamptothecin topoisomerase I inhibitors: update and perspectives JO - Mol Cancer Ther VL - 8 UR - https://doi.org/10.1158/1535-7163.MCT-08-0706 DO - 10.1158/1535-7163.MCT-08-0706 ID - Pommier2009 ER - TY - JOUR AU - King, I. F. AU - Yandava, C. N. AU - Mabb, A. M. AU - Hsiao, J. S. AU - Huang, H. S. AU - Pearson, B. L. AU - Calabrese, J. M. AU - Starmer, J. AU - Parker, J. S. AU - Magnuson, T. PY - 2013 DA - 2013// TI - Topoisomerases facilitate transcription of long genes linked to autism JO - Nature VL - 501 UR - https://doi.org/10.1038/nature12504 DO - 10.1038/nature12504 ID - King2013 ER - TY - JOUR AU - Bomgaars, L. PY - 2001 DA - 2001// TI - The development of camptothecin analogs in childhood cancers JO - Oncologist VL - 6 UR - https://doi.org/10.1634/theoncologist.6-6-506 DO - 10.1634/theoncologist.6-6-506 ID - Bomgaars2001 ER - TY - JOUR AU - Philpot, B. D. AU - Thompson, C. E. AU - Franco, L. AU - Williams, C. A. PY - 2011 DA - 2011// TI - Angelman syndrome: advancing the research frontier of neurodevelopmental disorders JO - J Neurodev Disord VL - 3 UR - https://doi.org/10.1007/s11689-010-9066-z DO - 10.1007/s11689-010-9066-z ID - Philpot2011 ER - TY - JOUR AU - Rodriguez-Galindo, C. AU - Poquette, C. A. AU - Marina, N. M. AU - Head, D. R. AU - Cain, A. AU - Meyer, W. H. AU - Santana, V. M. AU - Pappo, A. S. PY - 2000 DA - 2000// TI - Hematologic abnormalities and acute myeloid leukemia in children and adolescents administered intensified chemotherapy for the Ewing sarcoma family of tumors JO - J Pediatr Hematol Oncol VL - 22 UR - https://doi.org/10.1097/00043426-200007000-00008 DO - 10.1097/00043426-200007000-00008 ID - Rodriguez-Galindo2000 ER - TY - JOUR AU - Blaney, S. M. AU - Phillips, P. C. AU - Packer, R. J. AU - Heideman, R. L. AU - Berg, S. L. AU - Adamson, P. C. AU - Allen, J. C. AU - Sallan, S. E. AU - Jakacki, R. I. AU - Lange, B. J. PY - 1996 DA - 1996// TI - Phase II evaluation of topotecan for pediatric central nervous system tumors JO - Cancer VL - 78 UR - https://doi.org/3.0.CO;2-# DO - 3.0.CO;2-# ID - Blaney1996 ER - TY - JOUR AU - Feun, L. AU - Savaraj, N. PY - 2008 DA - 2008// TI - Topoisomerase I inhibitors for the treatment of brain tumors JO - Expert Rev Anticancer Ther VL - 8 UR - https://doi.org/10.1586/14737140.8.5.707 DO - 10.1586/14737140.8.5.707 ID - Feun2008 ER - TY - JOUR AU - Minturn, J. E. AU - Janss, A. J. AU - Fisher, P. G. AU - Allen, J. C. AU - Patti, R. AU - Phillips, P. C. AU - Belasco, J. B. PY - 2010 DA - 2010// TI - A phase II study of metronomic oral topotecan for recurrent childhood brain tumors JO - Pediatr Blood Cancer VL - 56 UR - https://doi.org/10.1002/pbc.22690 DO - 10.1002/pbc.22690 ID - Minturn2010 ER - TY - JOUR AU - El-Gizawy, S. A. AU - Hedaya, M. A. PY - 1999 DA - 1999// TI - Comparative brain tissue distribution of camptothecin and topotecan in the rat JO - Cancer Chemother Pharmacol VL - 43 UR - https://doi.org/10.1007/s002800050908 DO - 10.1007/s002800050908 ID - El-Gizawy1999 ER - TY - JOUR AU - Motl, S. AU - Zhuang, Y. AU - Waters, C. M. AU - Stewart, C. F. PY - 2006 DA - 2006// TI - Pharmacokinetic considerations in the treatment of CNS tumours JO - Clin Pharmacokinet VL - 45 UR - https://doi.org/10.2165/00003088-200645090-00002 DO - 10.2165/00003088-200645090-00002 ID - Motl2006 ER - TY - JOUR AU - Houghton, P. J. AU - Cheshire, P. J. AU - Hallman, J. D. AU - Lutz, L. AU - Friedman, H. S. AU - Danks, M. K. AU - Houghton, J. A. PY - 1995 DA - 1995// TI - Efficacy of topoisomerase I inhibitors, topotecan and irinotecan, administered at low dose levels in protracted schedules to mice bearing xenografts of human tumors JO - Cancer Chemother Pharmacol VL - 36 UR - https://doi.org/10.1007/BF00686188 DO - 10.1007/BF00686188 ID - Houghton1995 ER - TY - JOUR AU - Stone, J. B. AU - DeAngelis, L. M. PY - 2016 DA - 2016// TI - Cancer-treatment-induced neurotoxicity--focus on newer treatments JO - Nat Rev Clin Oncol VL - 13 UR - https://doi.org/10.1038/nrclinonc.2015.152 DO - 10.1038/nrclinonc.2015.152 ID - Stone2016 ER - TY - JOUR AU - Soffietti, R. AU - Trevisan, E. AU - Ruda, R. PY - 2014 DA - 2014// TI - Neurologic complications of chemotherapy and other newer and experimental approaches JO - Handb Clin Neurol VL - 121 UR - https://doi.org/10.1016/B978-0-7020-4088-7.00080-8 DO - 10.1016/B978-0-7020-4088-7.00080-8 ID - Soffietti2014 ER - TY - JOUR AU - Ioanoviciu, A. AU - Antony, S. AU - Pommier, Y. AU - Staker, B. L. AU - Stewart, L. AU - Cushman, M. PY - 2005 DA - 2005// TI - Synthesis and mechanism of action studies of a series of norindenoisoquinoline topoisomerase I poisons reveal an inhibitor with a flipped orientation in the ternary DNA−enzyme−inhibitor complex as determined by X-ray crystallographic analysis JO - J Med Chem VL - 48 UR - https://doi.org/10.1021/jm050076b DO - 10.1021/jm050076b ID - Ioanoviciu2005 ER - TY - JOUR AU - Marchand, C. AU - Antony, S. AU - Kohn, K. W. AU - Cushman, M. AU - Ioanoviciu, A. AU - Staker, B. L. AU - Burgin, A. B. AU - Stewart, L. AU - Pommier, Y. PY - 2006 DA - 2006// TI - A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex JO - Mol Cancer Ther VL - 5 UR - https://doi.org/10.1158/1535-7163.MCT-05-0456 DO - 10.1158/1535-7163.MCT-05-0456 ID - Marchand2006 ER - TY - JOUR AU - Staker, B. L. AU - Feese, M. D. AU - Cushman, M. AU - Pommier, Y. AU - Zembower, D. AU - Stewart, L. AU - Burgin, A. B. PY - 2005 DA - 2005// TI - Structures of three classes of anticancer agents bound to the human topoisomerase I−DNA covalent complex JO - J Med Chem VL - 48 UR - https://doi.org/10.1021/jm049146p DO - 10.1021/jm049146p ID - Staker2005 ER - TY - JOUR AU - Mabb, A. M. AU - Simon, J. M. AU - King, I. F. AU - Lee, H. M. AU - An, L. K. AU - Philpot, B. D. AU - Zylka, M. J. PY - 2016 DA - 2016// TI - Topoisomerase 1 regulates gene expression in neurons through cleavage complex-dependent and -independent mechanisms JO - PLoS One VL - 11 UR - https://doi.org/10.1371/journal.pone.0156439 DO - 10.1371/journal.pone.0156439 ID - Mabb2016 ER - TY - JOUR AU - Antony, S. AU - Kohlhagen, G. AU - Agama, K. AU - Jayaraman, M. AU - Cao, S. AU - Durrani, F. A. AU - Rustum, Y. M. AU - Cushman, M. AU - Pommier, Y. PY - 2005 DA - 2005// TI - Cellular topoisomerase I inhibition and antiproliferative activity by MJ-III-65 (NSC 706744), an indenoisoquinoline topoisomerase I poison JO - Mol Pharmacol VL - 67 UR - https://doi.org/10.1124/mol.104.003889 DO - 10.1124/mol.104.003889 ID - Antony2005 ER - TY - JOUR AU - Cushman, M. AU - Jayaraman, M. AU - Vroman, J. A. AU - Fukunaga, A. K. AU - Fox, B. M. AU - Kohlhagen, G. AU - Strumberg, D. AU - Pommier, Y. PY - 2000 DA - 2000// TI - Synthesis of new Indeno[1, 2-c]isoquinolines: cytotoxic con-camptothecin topoisomerase I inhibitors JO - J Med Chem VL - 43 UR - https://doi.org/10.1021/jm000029d DO - 10.1021/jm000029d ID - Cushman2000 ER - TY - JOUR AU - Fox, B. M. AU - Xiao, X. AU - Antony, S. AU - Kohlhagen, G. AU - Pommier, Y. AU - Staker, B. L. AU - Stewart, L. AU - Cushman, M. PY - 2003 DA - 2003// TI - Design, synthesis, and biological evaluation of cytotoxic 11-alkenylindenoisoquinoline topoisomerase I inhibitors and indenoisoquinoline−camptothecin hybrids JO - J Med Chem VL - 46 UR - https://doi.org/10.1021/jm0300476 DO - 10.1021/jm0300476 ID - Fox2003 ER - TY - JOUR AU - Strumberg, D. AU - Pommier, Y. AU - Paull, K. AU - Jayaraman, M. AU - Nagafuji, P. AU - Cushman, M. PY - 1999 DA - 1999// TI - Synthesis of cytotoxic indenoisoquinoline topoisomerase I poisons JO - J Med Chem VL - 42 UR - https://doi.org/10.1021/jm9803323 DO - 10.1021/jm9803323 ID - Strumberg1999 ER - TY - JOUR AU - Kinders, R. J. AU - Hollingshead, M. AU - Lawrence, S. AU - Ji, J. AU - Tabb, B. AU - Bonner, W. M. AU - Pommier, Y. AU - Rubinstein, L. AU - Evrard, Y. A. AU - Parchment, R. E. PY - 2010 DA - 2010// TI - Development of a validated immunofluorescence assay for gammaH2AX as a pharmacodynamic marker of topoisomerase I inhibitor activity JO - Clinical cancer research : an official journal of the American Association for Cancer Research VL - 16 UR - https://doi.org/10.1158/1078-0432.CCR-09-3076 DO - 10.1158/1078-0432.CCR-09-3076 ID - Kinders2010 ER - TY - JOUR AU - Antony, S. AU - Agama, K. K. AU - Miao, Z. H. AU - Takagi, K. AU - Wright, M. H. AU - Robles, A. I. AU - Varticovski, L. AU - Nagarajan, M. AU - Morrell, A. AU - Cushman, M. PY - 2007 DA - 2007// TI - Novel indenoisoquinolines NSC 725776 and NSC 724998 produce persistent topoisomerase I cleavage complexes and overcome multidrug resistance JO - Cancer Res VL - 67 UR - https://doi.org/10.1158/0008-5472.CAN-07-0938 DO - 10.1158/0008-5472.CAN-07-0938 ID - Antony2007 ER - TY - JOUR AU - Nagarajan, M. AU - Morrell, A. AU - Ioanoviciu, A. AU - Antony, S. AU - Kohlhagen, G. AU - Agama, K. AU - Hollingshead, M. AU - Pommier, Y. AU - Cushman, M. PY - 2006 DA - 2006// TI - Synthesis and evaluation of indenoisoquinoline topoisomerase I inhibitors substituted with nitrogen heterocycles JO - J Med Chem VL - 49 UR - https://doi.org/10.1021/jm060564z DO - 10.1021/jm060564z ID - Nagarajan2006 ER - TY - JOUR AU - Kummar, S. AU - Chen, A. AU - Gutierrez, M. AU - Pfister, T. D. AU - Wang, L. AU - Redon, C. AU - Bonner, W. M. AU - Yutzy, W. AU - Zhang, Y. AU - Kinders, R. J. PY - 2016 DA - 2016// TI - Clinical and pharmacologic evaluation of two dosing schedules of indotecan (LMP400), a novel indenoisoquinoline, in patients with advanced solid tumors JO - Cancer Chemother Pharmacol VL - 78 UR - https://doi.org/10.1007/s00280-016-2998-6 DO - 10.1007/s00280-016-2998-6 ID - Kummar2016 ER - TY - JOUR AU - Jiang, Y. H. AU - Armstrong, D. AU - Albrecht, U. AU - Atkins, C. M. AU - Noebels, J. L. AU - Eichele, G. AU - Sweatt, J. D. AU - Beaudet, A. L. PY - 1998 DA - 1998// TI - Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation JO - Neuron VL - 21 UR - https://doi.org/10.1016/S0896-6273(00)80596-6 DO - 10.1016/S0896-6273(00)80596-6 ID - Jiang1998 ER - TY - JOUR AU - Dindot, S. V. AU - Antalffy, B. A. AU - Bhattacharjee, M. B. AU - Beaudet, A. L. PY - 2008 DA - 2008// TI - The Angelman syndrome ubiquitin ligase localizes to the synapse and nucleus, and maternal deficiency results in abnormal dendritic spine morphology JO - Hum Mol Genet VL - 17 UR - https://doi.org/10.1093/hmg/ddm288 DO - 10.1093/hmg/ddm288 ID - Dindot2008 ER - TY - JOUR AU - Beck, D. E. AU - Agama, K. AU - Marchand, C. AU - Chergui, A. AU - Pommier, Y. AU - Cushman, M. PY - 2014 DA - 2014// TI - Synthesis and biological evaluation of new carbohydrate-substituted indenoisoquinoline topoisomerase I inhibitors and improved syntheses of the experimental anticancer agents indotecan (LMP400) and indimitecan (LMP776) JO - J Med Chem VL - 57 UR - https://doi.org/10.1021/jm401814y DO - 10.1021/jm401814y ID - Beck2014 ER - TY - JOUR AU - Kim, Y. AU - Lee, H. M. AU - Xiong, Y. AU - Sciaky, N. AU - Hulbert, S. W. AU - Cao, X. AU - Everitt, J. I. AU - Jin, J. AU - Roth, B. L. AU - Jiang, Y. H. PY - 2017 DA - 2017// TI - Targeting the histone methyltransferase G9a activates imprinted genes and improves survival of a mouse model of Prader-Willi syndrome JO - Nat Med VL - 23 UR - https://doi.org/10.1038/nm.4257 DO - 10.1038/nm.4257 ID - Kim2017 ER - TY - JOUR AU - Carpenter, A. E. AU - Jones, T. R. AU - Lamprecht, M. R. AU - Clarke, C. AU - Kang, I. H. AU - Friman, O. AU - Guertin, D. A. AU - Chang, J. H. AU - Lindquist, R. A. AU - Moffat, J. PY - 2006 DA - 2006// TI - CellProfiler: image analysis software for identifying and quantifying cell phenotypes JO - Genome Biol VL - 7 UR - https://doi.org/10.1186/gb-2006-7-10-r100 DO - 10.1186/gb-2006-7-10-r100 ID - Carpenter2006 ER - TY - BOOK AU - Guo, J. AU - Holleran, J. AU - Schmitz, J. C. AU - Czambel, K. AU - Beumer, J. H. AU - Eiseman, J. L. PY - 2015 DA - 2015// TI - Pharmacokinetics and pharmacodynamics of indenoisoquinoline LMP400 (indotecan) in BALB/c female mice bearing CT-26 colon tumors. [abstract]. Proceedings of the 106th Annual Meeting of the American Association for. Cancer Research ID - Guo2015 ER - TY - JOUR AU - Pommier, Y. PY - 2006 DA - 2006// TI - Topoisomerase I inhibitors: camptothecins and beyond JO - Nat Rev Cancer VL - 6 UR - https://doi.org/10.1038/nrc1977 DO - 10.1038/nrc1977 ID - Pommier2006 ER - TY - JOUR AU - Pommier, Y. AU - Sun, Y. AU - Huang, S. N. AU - Nitiss, J. L. PY - 2016 DA - 2016// TI - Roles of eukaryotic topoisomerases in transcription, replication and genomic stability JO - Nat Rev Mol Cell Biol VL - 17 UR - https://doi.org/10.1038/nrm.2016.111 DO - 10.1038/nrm.2016.111 ID - Pommier2016 ER - TY - JOUR AU - Garst, J. PY - 2007 DA - 2007// TI - Safety of topotecan in the treatment of recurrent small-cell lung cancer and ovarian cancer JO - Expert Opin Drug Saf VL - 6 UR - https://doi.org/10.1517/14740338.6.1.53 DO - 10.1517/14740338.6.1.53 ID - Garst2007 ER - TY - JOUR AU - Fuchs, C. AU - Mitchell, E. P. AU - Hoff, P. M. PY - 2006 DA - 2006// TI - Irinotecan in the treatment of colorectal cancer JO - Cancer Treat Rev VL - 32 UR - https://doi.org/10.1016/j.ctrv.2006.07.001 DO - 10.1016/j.ctrv.2006.07.001 ID - Fuchs2006 ER - TY - JOUR AU - Antony, S. AU - Jayaraman, M. AU - Laco, G. AU - Kohlhagen, G. AU - Kohn, K. W. AU - Cushman, M. AU - Pommier, Y. PY - 2003 DA - 2003// TI - Differential induction of topoisomerase I-DNA cleavage complexes by the indenoisoquinoline MJ-III-65 (NSC 706744) and camptothecin: base sequence analysis and activity against camptothecin-resistant topoisomerases I JO - Cancer Res VL - 63 ID - Antony2003 ER - TY - JOUR AU - Mabb, A. M. AU - Kullmann, P. H. AU - Twomey, M. A. AU - Miriyala, J. AU - Philpot, B. D. AU - Zylka, M. J. PY - 2014 DA - 2014// TI - Topoisomerase 1 inhibition reversibly impairs synaptic function JO - Proc Natl Acad Sci U S A VL - 111 UR - https://doi.org/10.1073/pnas.1413204111 DO - 10.1073/pnas.1413204111 ID - Mabb2014 ER - TY - JOUR AU - Solier, S. AU - Ryan, M. C. AU - Martin, S. E. AU - Varma, S. AU - Kohn, K. W. AU - Liu, H. AU - Zeeberg, B. R. AU - Pommier, Y. PY - 2013 DA - 2013// TI - Transcription poisoning by topoisomerase I is controlled by gene length, splice sites, and miR-142-3p JO - Cancer Res VL - 73 UR - https://doi.org/10.1158/0008-5472.CAN-12-3504 DO - 10.1158/0008-5472.CAN-12-3504 ID - Solier2013 ER - TY - JOUR AU - Nagarajan, M. AU - Xiao, X. AU - Antony, S. AU - Kohlhagen, G. AU - Pommier, Y. AU - Cushman, M. PY - 2003 DA - 2003// TI - Design, synthesis, and biological evaluation of indenoisoquinoline topoisomerase I inhibitors featuring polyamine side chains on the lactam nitrogen JO - J Med Chem VL - 46 UR - https://doi.org/10.1021/jm030313f DO - 10.1021/jm030313f ID - Nagarajan2003 ER - TY - JOUR AU - Cinelli, M. A. AU - Reddy, P. V. AU - Lv, P. C. AU - Liang, J. H. AU - Chen, L. AU - Agama, K. AU - Pommier, Y. AU - van Breemen, R. B. AU - Cushman, M. PY - 2012 DA - 2012// TI - Identification, synthesis, and biological evaluation of metabolites of the experimental cancer treatment drugs indotecan (LMP400) and indimitecan (LMP776) and investigation of isomerically hydroxylated indenoisoquinoline analogues as topoisomerase I poisons JO - J Med Chem VL - 55 UR - https://doi.org/10.1021/jm300519w DO - 10.1021/jm300519w ID - Cinelli2012 ER -