Fig. 5From: Modeling the neuropsychiatric manifestations of Lowe syndrome using induced pluripotent stem cells: defective F-actin polymerization and WAVE-1 expression in neuronal cellsa. Immunocytochemistry showing WAVE-1 expression pattern in NPCs. The control samples (LS200, 400 and 600; 690C) show a robust staining pattern with localization to the cytoskeleton. In the patient samples (LS100, 300 and 500), expression is patchy and large inclusions are seen. Inclusions are not seen in the 690KO line. The WAVE-1 inclusions were observed in duplicate NPC samples. b. WAVE-1 expression by quantitative immunocytochemistry. Differences between control and patient samples were not statistically significant using Student’s t test, two-tailed. Error bars are standard deviationsBack to article page