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Table 1 Resveratrol reverses and prevents prenatal progestin exposure-induced ERβ suppression and autism-like behavior

From: Resveratrol ameliorates prenatal progestin exposure-induced autism-like behavior through ERβ activation

Rats

Postnatal treatment of RSV

Prenatal treatment of RSV

Prenatal progestin exposure

ERβ mRNA level (%)

Social interaction time (seconds)

ERβ mRNA level (%)

Social interaction time (seconds)

Control

RSV

Control

RSV

Control

RSV

Control

RSV

Vehicle

100 ± 9

111 ± 10

351 ± 27

369 ± 17

100 ± 11

91 ± 11

356 ± 24

340 ± 16

E2

94 ± 12

91 ± 13

369 ± 24

343 ± 16

89 ± 13

95 ± 9

341 ± 17

336 ± 19

P4

78 ± 10*

119 ± 9

321 ± 17

339 ± 22

78 ± 8*

106 ± 8

319 ± 22

369 ± 23

LNG

54 ± 11*

89 ± 12

259 ± 19*

321 ± 19

61 ± 9*

109 ± 11

263 ± 12*

335 ± 17

MPA

72 ± 13*

115 ± 7

261 ± 24*

351 ± 28

66 ± 12*

92 ± 8

245 ± 11*

361 ± 22

NES

81 ± 11

91 ± 9

249 ± 20*

298 ± 23*

75 ± 8*

111 ± 12

266 ± 18*

350 ± 18

NET

49 ± 8*

106 ± 11

237 ± 16*

326 ± 20

55 ± 10*

106 ± 9

220 ± 25*

348 ± 20

NETA

67 ± 9*

90 ± 9

286 ± 19*

378 ± 14

72 ± 13*

113 ± 11

301 ± 17*

356 ± 25

NEN

75 ± 8*

113 ± 12

336 ± 26

361 ± 15

69 ± 14*

78 ± 9*

321 ± 25

336 ± 21

NGM

85 ± 12

90 ± 8

279 ± 22*

306 ± 22*

78 ± 9*

135 ± 11*

291 ± 23*

343 ± 24

OHPC

59 ± 10

109 ± 11

268 ± 19*

322 ± 21

63 ± 11*

106 ± 12*

287 ± 19*

326 ± 22

  1. n = 8, results are expressed as mean ± SEM
  2. Note: E2, 17β-estradiol; P4, progesterone; LNG, levonorgestrel; MPA, medroxyprogesterone acetate; NES, nestorone; NET, norethindrone; NETA, norethindrone acetate; NEN, norethynodrel; NGM, norgestimate; OHPC, hydroxyprogesterone caproate; RSV, resveratrol.
  3. *P < 0.05, vs vehicle group in the same column