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Table 1 Resveratrol reverses and prevents prenatal progestin exposure-induced ERβ suppression and autism-like behavior

From: Resveratrol ameliorates prenatal progestin exposure-induced autism-like behavior through ERβ activation

Rats Postnatal treatment of RSV Prenatal treatment of RSV
Prenatal progestin exposure ERβ mRNA level (%) Social interaction time (seconds) ERβ mRNA level (%) Social interaction time (seconds)
Control RSV Control RSV Control RSV Control RSV
Vehicle 100 ± 9 111 ± 10 351 ± 27 369 ± 17 100 ± 11 91 ± 11 356 ± 24 340 ± 16
E2 94 ± 12 91 ± 13 369 ± 24 343 ± 16 89 ± 13 95 ± 9 341 ± 17 336 ± 19
P4 78 ± 10* 119 ± 9 321 ± 17 339 ± 22 78 ± 8* 106 ± 8 319 ± 22 369 ± 23
LNG 54 ± 11* 89 ± 12 259 ± 19* 321 ± 19 61 ± 9* 109 ± 11 263 ± 12* 335 ± 17
MPA 72 ± 13* 115 ± 7 261 ± 24* 351 ± 28 66 ± 12* 92 ± 8 245 ± 11* 361 ± 22
NES 81 ± 11 91 ± 9 249 ± 20* 298 ± 23* 75 ± 8* 111 ± 12 266 ± 18* 350 ± 18
NET 49 ± 8* 106 ± 11 237 ± 16* 326 ± 20 55 ± 10* 106 ± 9 220 ± 25* 348 ± 20
NETA 67 ± 9* 90 ± 9 286 ± 19* 378 ± 14 72 ± 13* 113 ± 11 301 ± 17* 356 ± 25
NEN 75 ± 8* 113 ± 12 336 ± 26 361 ± 15 69 ± 14* 78 ± 9* 321 ± 25 336 ± 21
NGM 85 ± 12 90 ± 8 279 ± 22* 306 ± 22* 78 ± 9* 135 ± 11* 291 ± 23* 343 ± 24
OHPC 59 ± 10 109 ± 11 268 ± 19* 322 ± 21 63 ± 11* 106 ± 12* 287 ± 19* 326 ± 22
  1. n = 8, results are expressed as mean ± SEM
  2. Note: E2, 17β-estradiol; P4, progesterone; LNG, levonorgestrel; MPA, medroxyprogesterone acetate; NES, nestorone; NET, norethindrone; NETA, norethindrone acetate; NEN, norethynodrel; NGM, norgestimate; OHPC, hydroxyprogesterone caproate; RSV, resveratrol.
  3. *P < 0.05, vs vehicle group in the same column