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Table 4 Enrichment statistics for meQTL targets in ASD-related CpG sites

From: Case-control meta-analysis of blood DNA methylation and autism spectrum disorder

  

meQTL p value thresholdb

Permissivec

Intermediated

Stringente

ASD EWAS p valuea

1 × 10−3

1.20 (0.041)

1.11 (0.218)

1.11 (0.243)

1 × 10−4

1.46 (0.134)

1.71 (0.089)

1.50 (0.205)

  1. Enrichment fold statistics and p values based on 1000 permutations are reported
  2. aASD to DNAm association p value defined from meta-analysis
  3. bSNP to CpG association p value thresholds
  4. cp values in each methylation processing batch that allowed for 100% power to detect a 5% methylation difference with each addition of minor allele (see “Methods”)
  5. dp values in each methylation processing batch that allowed for 90% power to detect same methylation difference
  6. ep values in each methylation processing batch that allowed for 80% power to detect same methylation difference