Case-control meta-analysis of blood DNA methylation and autism spectrum disorder

Table 3 Suggestively associated (p < 1 × 10⁻⁵) CpG sites in peripheral blood and their corresponding effect sizes in three brain regions

Probe ID	CHR	Position	SEED mean diff^a	SSC mean diff^a	Weighted average mean diff^b	PFC^a,c	TC^a,d	CER^a,e
cg21151899	22	42,337,657	0.78	0.54	0.68	1.60	4.07	1.64
cg03731974	16	86,531,598	0.09	0.08	0.08	0.20	− 7.18	0.74
cg09962502	2	96,971,189	− 0.05	− 0.08	− 0.06	− 2.50	− 0.43	− 1.34
cg01798266	1	1.53E+08	− 0.43	− 0.13	− 0.31	− 2.70	− 0.91	0.87
cg01716316	17	40,897,182	− 0.09	− 0.13	− 0.1	− 0.30	− 0.02	0.39
cg16234726	14	1.02E+08	− 0.2	− 0.37	− 0.27	0.50	− 0.3	− 0.03
cg09671955	1	1.69E+08	− 0.47	− 1.25	− 0.79	− 1.40	− 1.38	− 5.11

^aMean difference values computed as mean in cases − mean in controls
^bAverage of SEED and SSC mean difference values weighted by sample size (N_SEED = 968, N_SSC = 686)
^cPrefrontal cortex data from Ladd-Acosta et al. [19]
^dTemporal cortex data from Ladd-Acosta et al. [19]
^eCerebellum data from Ladd-Acosta et al. [19]