Table 2 Change in outcome scores over the 12-week study period

Aberrant behavior checklist total score

103.9 (72.0 to 135.9)

94.2 (63.8 to 124.6)

96.9 (65.7 to 128.0)

− 9.7 (− 17.6 to − 1.8)

0.02*

− 7.1 (− 17.4 to 3.2)

0.18

 Hyperactivity

29.4 (21.1 to 37.8)

27.7 (19.0 to 36.4)

28.0 (20.1 to 35.8)

− 1.7 (− 4.5 to 1.1)

0.24

− 1.5 (− 5.0 to 2.0)

0.41

 Irritability

25.0 (12.9 to 37.1)

22.2 (9.3 to 35.2)

22.8 (10.1 to 35.5)

− 2.8 (− 6.1 to 0.6)

0.11

− 2.2 (− 5.8 to 1.3)

0.22

 Inappropriateness

5.3 (−0.4 to 10.9)

5.0 (− 0.8 to 10.8)

5.0 (−1.0 to 11.1)

− 0.3 (− 0.8 to 0.3)

0.35

− 0.2 (− 1.3 to 0.9)

0.72

 Social withdrawal

34.3 (22.8 to 45.7)

30.7 (20.3 to 41.0)

31.2 (19.8 to 42.7)

− 3.6 (− 5.8 to − 1.4)

0.001*

− 3.0 (− 5.6 to − 0.4)

0.02*

 Stereotypy

9.9 (6.5 to 13.4)

8.4 (4.9 to 11.8)

9.8 (6.5 to 13.1)

− 1.5 (− 2.8 to − 0.3)

0.02*

− 0.09 (− 1.8 to 1.6)

0.92

Social responsiveness scale total score

154.1 (106.6 to 201.7)

147.0 (99.9 to 194.1)

144.4 (95.5 to 193.3)

− 7.1 (− 16.9 to 2.6)

0.15

−9.7 (− 18.7 to − 0.8)

0.03*

 Awareness

22.2 (15.7 to 28.7)

22.5 (16.2 to 28.7)

22.7 (15.8 to 29.5)

0.3 (− 0.9 to 1.4)

0.65

0.5 (− 1.2 to 2.1)

0.60

 Cognition

26.6 (15.3 to 37.9)

25.4 (12.8 to 38.0)

25.1 (14.0 to 36.3)

− 1.2 (− 4.2 to 1.9)

0.44

− 1.5 (− 4.1 to 1.1)

0.27

 Communication

55.6 (35.3 to 75.9)

52.7 (32.8 to 72.7)

50.6 (30.5 to 70.8)

− 2.9 (− 6.5 to 0.8)

0.13

− 5.0 (− 8.4 to −1.5)

0.005*

 Mannerisms

24.1 (19.1 to 29.1)

22.7 (16.7 to 28.7)

22.8 (17.3 to 28.3)

− 1.5 (− 3.3 to 0.4)

0.12

− 1.3 (− 3.7 to 1.1)

0.28

 Motivation

27.1 (17.5 to 36.8)

24.6 (15.5 to 33.6)

24.0 (13.6 to 34.3)

− 2.6 (− 4.2 to − 0.9)

0.003*

− 3.1 (− 5.1 to − 1.2)

0.001*