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Table 2 Change in outcome scores over the 12-week study period

From: Identification of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli

Outcome measure Adjusted mean scores (95% CI) Change from baseline (95% CI)
  Baseline 1 month 3 months 1 month p 3 months p
Aberrant behavior checklist total score 103.9 (72.0 to 135.9) 94.2 (63.8 to 124.6) 96.9 (65.7 to 128.0) − 9.7 (− 17.6 to − 1.8) 0.02* − 7.1 (− 17.4 to 3.2) 0.18
 Hyperactivity 29.4 (21.1 to 37.8) 27.7 (19.0 to 36.4) 28.0 (20.1 to 35.8) − 1.7 (− 4.5 to 1.1) 0.24 − 1.5 (− 5.0 to 2.0) 0.41
 Irritability 25.0 (12.9 to 37.1) 22.2 (9.3 to 35.2) 22.8 (10.1 to 35.5) − 2.8 (− 6.1 to 0.6) 0.11 − 2.2 (− 5.8 to 1.3) 0.22
 Inappropriateness 5.3 (−0.4 to 10.9) 5.0 (− 0.8 to 10.8) 5.0 (−1.0 to 11.1) − 0.3 (− 0.8 to 0.3) 0.35 − 0.2 (− 1.3 to 0.9) 0.72
 Social withdrawal 34.3 (22.8 to 45.7) 30.7 (20.3 to 41.0) 31.2 (19.8 to 42.7) − 3.6 (− 5.8 to − 1.4) 0.001* − 3.0 (− 5.6 to − 0.4) 0.02*
 Stereotypy 9.9 (6.5 to 13.4) 8.4 (4.9 to 11.8) 9.8 (6.5 to 13.1) − 1.5 (− 2.8 to − 0.3) 0.02* − 0.09 (− 1.8 to 1.6) 0.92
Social responsiveness scale total score 154.1 (106.6 to 201.7) 147.0 (99.9 to 194.1) 144.4 (95.5 to 193.3) − 7.1 (− 16.9 to 2.6) 0.15 −9.7 (− 18.7 to − 0.8) 0.03*
 Awareness 22.2 (15.7 to 28.7) 22.5 (16.2 to 28.7) 22.7 (15.8 to 29.5) 0.3 (− 0.9 to 1.4) 0.65 0.5 (− 1.2 to 2.1) 0.60
 Cognition 26.6 (15.3 to 37.9) 25.4 (12.8 to 38.0) 25.1 (14.0 to 36.3) − 1.2 (− 4.2 to 1.9) 0.44 − 1.5 (− 4.1 to 1.1) 0.27
 Communication 55.6 (35.3 to 75.9) 52.7 (32.8 to 72.7) 50.6 (30.5 to 70.8) − 2.9 (− 6.5 to 0.8) 0.13 − 5.0 (− 8.4 to −1.5) 0.005*
 Mannerisms 24.1 (19.1 to 29.1) 22.7 (16.7 to 28.7) 22.8 (17.3 to 28.3) − 1.5 (− 3.3 to 0.4) 0.12 − 1.3 (− 3.7 to 1.1) 0.28
 Motivation 27.1 (17.5 to 36.8) 24.6 (15.5 to 33.6) 24.0 (13.6 to 34.3) − 2.6 (− 4.2 to − 0.9) 0.003* − 3.1 (− 5.1 to − 1.2) 0.001*
  1. Mean change scores were adjusted for age and gender
  2. *Statistically significant change from baseline