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Table 6 COBRA-derived percentages of AluS methylation and patterns in LCLs from ASD individuals and sex- and age-matched controls

From: Integrated genome-wide Alu methylation and transcriptome profiling analyses reveal novel epigenetic regulatory networks associated with autism spectrum disorder

Comparison Sample groups Age (mean ± SD) Percentages of AluS methylation patterns
%mC %mCmC %uCmC %mCuC %uCuC
ASD vs. control (sex- and age-matched) Control (n = 20) 15 ± 6.97 37.98 ± 1.36 25.70 ± 2.36 18.71 ± 1.15 21.76 ± 1.03 33.83 ± 1.69
ASD (n = 36) 13.4 ± 4.55 37.86 ± 2.07 25.92 ± 2.69 18.72 ± 1.66 21.22 ± 1.76 34.13 ± 3.00
P value 0.866 0.866 0.974 0.315 0.845
Subgroup M vs. control (sex- and age-matched) Control (n = 10) 12.1 ± 3.81 38.07 ± 1.52 25.57 ± 2.31 18.76 ± 0.87 22.06 ± 0.69 33.62 ± 1.85
ASD subgroup M (n = 10) 12.1 ± 3.73 39.03 ± 1.16 25.17 ± 1.15 20.06 ± 0.92 22.99 ± 0.82 31.77 ± 1.76
P value 0.293 0.845 0.043 0.089 0.168
Subgroup L vs. control (sex- and age-matched) Control (n = 6) 13.7 ± 1.64 37.84 ± 1.51 24.88 ± 2.94 19.10 ± 1.60 22.25 ± 1.03 33.77 ± 1.84
ASD subgroup L (n = 6) 13.5 ± 1.97 36.024 ± 1.43 23.37 ± 2.63 19.32 ± 1.69 20.93 ± 2.52 36.38 ± 2.29
P value 0.168 0.569 0.866 0.502 0.168
Subgroup S vs. control (sex- and age-matched) Control (n = 20) 15 ± 6.97 37.98 ± 1.36 25.70 ± 2.36 18.71 ± 1.15 21.76 ± 1.03 33.83 ± 1.69
ASD subgroup S (n = 20) 15 ± 5.41 37.83 ± 2.23 27.06 ± 2.67 17.88 ± 1.44 20.43 ± 1.17 34.64 ± 3.00
P value 0.866 0.242 0.168 0.010 0.502
  1. The percentages of AluS methylation patterns were determined based on four patterns: the hypermethylated pattern (mCmC), two partially methylated patterns (mCuC, uCmC), and the hypomethylated pattern (uCuC). Comparisons of the methylation status between ASD and sex- and age-matched unaffected control groups and between ASD phenotypic subgroups and the matched unaffected controls were also performed. Statistically significant P values < 0.05 with Benjamini-Hochberg correction (FDR = 0.05) are shown in italics