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Fig. 4 | Molecular Autism

Fig. 4

From: Analysis of neuroanatomical differences in mice with genetically modified serotonin transporters assessed by structural magnetic resonance imaging

Fig. 4

ad This figure shows significant voxelwise differences as measured using an ANOVA while factoring in both the sex and background of the mice. All 121 mice were used in this comparison. The panel on the right displays a coronal flythrough highlighting the location of volume differences found due to the Slc6a4 gene in both absolute and relative volume. For this figure, the C57Bl6/J mice from the Slc6a4 KO group were normalized to the C57Bl6/J mice from the Slc6a4 Ala56 KI group (see the “Methods” section). Slc6a4 KO (N = 39, 19 WT (9M, 10F), 20 KO (10M, 10F); Slc6a4 Ala56 KI (B6) (N = 40, 20 WT (10M, 10F), 20 KI (10M, 10F); Slc6a4 Ala 56 KI (129) (N = 42, 21 WT (11M, 10F), 21 KI (11M, 10F)

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