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Fig. 7 | Molecular Autism

Fig. 7

From: CRISPR/Cas9-induced shank3b mutant zebrafish display autism-like behaviors

Fig. 7

shank3b deficiency resulted in the reduction of post- and presynaptic proteins in adult zebrafish brain. a Quantitative immunoblot blot analysis showed that the postsynaptic protein homer1 was significantly decreased (27% of shank3b+/+) in the shank3b−/− male zebrafish brain relative to shank3b+/+ zebrafish (3.5 mpf, N = 3 for each group). b The expression of presynaptic synaptophysin protein was markedly reduced in shank3b−/− male zebrafish brain compared with that of shank3b+/+ zebrafish (3.5 mpf, 49% of shank3b+/+). N = 3 for each group. Data are presented as mean ± SEM; *p < 0.05, **p < 0.01

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