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Fig. 5 | Molecular Autism

Fig. 5

From: CRISPR/Cas9-induced shank3b mutant zebrafish display autism-like behaviors

Fig. 5

shank3b−/− zebrafish displayed social interaction defect. ab Schematic of shoaling test (a) and significantly increased inter-fish distance of adult male shank3b−/− zebrafish (3.5 mpf) (b). N = 18 for each group. cf Schematic of social preference test of adult male zebrafish (3.5 mpf) (c). Heat map (d) shows that shank3b+/+ zebrafish displayed significant higher frequency near a group of zebrafish than shank3b−/− zebrafish. Time ratio (e) and distance ratio (f) in the conspecific sector were significantly reduced in shank3b−/− zebrafish compared to shank3b+/+ zebrafish. N = 16 for each group. gh Schematic of kin recognition and preference test of adult male zebrafish (3.5 mpf) (g) and significantly reduced ratio of kin zone entering in shank3b−/− zebrafish compared to shank3+/+ zebrafish (h). N = 10 for each group. Data are presented as mean ± SEM; ****p < 0.0001

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