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Fig. 8 | Molecular Autism

Fig. 8

From: Analysis of the expression pattern of the schizophrenia-risk and intellectual disability gene TCF4 in the developing and adult brain suggests a role in development and plasticity of cortical and hippocampal neurons

Fig. 8

PTHS-associated brain anomalies in TCF4-haploinsufficient mice. Hypoplastic corpus callosum in Tcf4-haploinsufficient PTHS patients at the age of 3 years (B) and 7 years (D). A, C Age-matched references. E Small hippocampus in PTHS patient at the age of 7 years. Tcf4-haploinsufficient mice (F’, G’) show agenesis of the corpus callosum and reduced hippocampal volume (H) compared to WT mice (F, G). Cortical diameter was determined along the rostro-caudal axis (I). Representative images of the cortical thickness of Tcf4ex4WT/WT mice (J, L) and Tcf4ex4lacZ/WT mice (K, M). Cortical diameter of Tcf4ex4lacZ/WT mice was significantly decreased compared to Tcf4ex4WT/WT mice in all analyzed cortical regions. The results are displayed as mean in microns ± SD. N–P Scale bars 500 μm. The DG area was measured in six representative slices spanning a distance of 240 μm. Abbreviations: PTLp, posterior parietal association area; SSp-bfd, primary somatosensory area-barrel field; SSp-tr, primary somatosensory area-trunk; Rost, rostral; Caud, caudal

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Molecular Autism

ISSN: 2040-2392