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Fig. 2 | Molecular Autism

Fig. 2

From: 17-β estradiol increases parvalbumin levels in Pvalb heterozygous mice and attenuates behavioral phenotypes with relevance to autism core symptoms

Fig. 2

Reciprocal social interaction test. a The total social interaction time displayed by pairs of the same genotype during the 5-min social interaction period in the cohorts of PV+/+, PV+/−, and PV−/− mice, vehicle-treated or E2-treated. Asterisk represents *p < 0.05. b Time course of time spent in social interaction per 1-min bin (dashed line indicates introduction of partner mouse). Data are presented as mean ± SEM. c Percentage of non-social vs. social behavior following social behavior in PV+/+ wild-type littermate control mice, PV+/− heterozygous mice, and PV−/− mice treated with vehicle (c) or E2 (c’). The dashed line indicates 50% chance level. Black bar: social; striped bar: non-social. Asterisk represents p < 0.05 vs. non-social. Hashtag represents p < 0.05 vs. 50% chance level. d Representative ethograms of social and non-social behavior displayed during juvenile reciprocal social interactions by a PV+/+ wild-type littermate control mouse, a PV+/− heterozygous mouse, and a PV−/− null mutant mouse treated with vehicle (d; left) or E2 (d’; right)

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Molecular Autism

ISSN: 2040-2392