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Fig. 7 | Molecular Autism

Fig. 7

From: Impairment of social behaviors in Arhgef10 knockout mice

Fig. 7

MAO-A is decreased in Arhgef10 / mice. The main degradation enzymes 5-HT and NE were analyzed by Western blotting. a MAO-A expression was decreased in the frontal cortex and amygdala of Arhgef10 / mice. Another metabolizing enzyme, MOA-B, did not show a significant difference between WT and KO mice b. The main enzymes for the synthesis of the amine neurotransmitters were also analyzed by Western blotting. The protein levels of both DBH c and TPH d were similar between WT and KO mice in the examined brain areas. *p < 0.05 compared with WT. MAO-A monoamine oxidase A, MAO-B monoamine oxidase B, DBH dopamine β-hydroxylase, TPH tryptophan hydroxylase

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