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Fig. 5 | Molecular Autism

Fig. 5

From: Impairment of social behaviors in Arhgef10 knockout mice

Fig. 5

Arhgef10 knockout does not affect the startle response, pre-pulse inhibition (PPI) or learning. The startle reflex response was measured as startle amplitude, and PPI is the reduction of this response when an acoustic startle (120 dB) is preceded by a stimulus of 70, 74, or 82 dB. a There was no difference between WT and Arhgef10 / mice in startle responses to a 120-dB acoustic stimulus. b Arhgef10 / mice did not show a PPI deficit for a pre-pulse of 70, 74, or 82 dB (n = 5–6). c In the Morris water maze test, all mice were trained for 4 days to reach the platform. d On day 5, the platform was removed for the probe test to examine the memory of the animals. Note that Arhgef10 / mice exhibit the same normal acquisition curve as WT mice. Both WT and Arhgef10 / mice spent much more time in the target zone than in any other zone in the probe test. The bar graph shows the mean ± SEM (n = 6–7). *p < 0.05 compared with adjacent or opposite quadrants

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