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Fig. 4 | Molecular Autism

Fig. 4

From: Impairment of social behaviors in Arhgef10 knockout mice

Fig. 4

Reduced anxiety-like and depression-related behavior in Arhgef10 / mice. Anxiety-like behavior was tested in an elevated plus maze (EPM) for 5 min. For depression-related behavior, immobility was measured between 2 and 6 min in the forced swim test (FST) and the tail suspension test (TST). a Arhgef10 / mice spent more time in open arms than WT mice (n = 13 for each) in the EPM. b Total entries into open arms and closed arms of the EPM in WT and Arhgef10 / mice. c Reduced immobility time was observed in Arhgef10 / mice (n = 9 and 10 for WT and KO, respectively) during the FST. d Arhgef10 / mice also displayed reduced immobility time compared with WT mice during the TST (n = 9 and 10 for WT and KO, respectively). The bar graph shows the mean ± SEM. *p < 0.05 compared with WT

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