Fig. 3

Arhgef10 knockout mice display spontaneous locomotor hyperactivity in the open field test. Spontaneous locomotor activity was tested in an open field for 60 min. a Total ambulatory locomotion (p = 0.001). b Time course of locomotor activity. Note that locomotor activity was greater in Arhgef10 knockout mice. c No difference between WT mice and Arhgef10 ⁻/⁻ mice in total rearing was observed. d No difference in percent of activity in the central part of the open field was observed between WT mice and Arhgef10 ⁻/⁻ mice. The bar graph shows mean ± SEM (n = 16 per genotype for WT mice and KO mice); * p < 0.05 compared with WT mice by one-way ANOVA