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Fig. 2 | Molecular Autism

Fig. 2

From: Impairment of social behaviors in Arhgef10 knockout mice

Fig. 2

Arhgef10 knockout mice exhibit social impairment in the three-chamber test. a The time spent in each of the three compartments was analyzed using EthoVision. b The active interaction times with the empty cylinder and an unfamiliar mouse (stranger 1) in the session were also evaluated. WT mice (n = 12) spent much more time in the chamber with stranger 1 than in the empty cylinder, and displayed more interaction with the mouse than with the empty cylinder, indicating normal sociability (p < 0.001). However, Arhgef10 / mice (n = 12) spent equal durations of both total time and active interaction time in the chamber with empty cylinder and stranger 1. d In the preference for social novelty test, the time spent in each chamber was analyzed as in the previous test. WT mice spent more time in the chamber with a novel mouse (stranger 2) than in the compartment with stranger 1. However, Arhgef10 −/− mice spent less time in the chamber with stranger 2 than in the chamber with stranger 1. e The duration of contact time was measured with stranger 1 and the novel mouse stranger 2. WT mice displayed a significant increase in the duration of close interaction with stranger 2 compared with stranger 1 (p < 0.001). However, Arhgef10 −/− mice did not show a preference for novel stranger 2

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