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Fig. 4 | Molecular Autism

Fig. 4

From: Insulin receptor sensitization restores neocortical excitation/inhibition balance in a mouse model of autism

Fig. 4

Insulin sensitization-increased inhibition in Met-EMx1 brain slices. ac Example records of GABAA receptor-mediated sIPSCs in Met-EMx1 cortical neurons without drug application, and with insulin alone (I) or insulin + pioglitazone (I + P) applications. d Cumulative fraction curves of the sIPSC amplitudes show a significant shift of the amplitude distribution for insulin + pioglitazone condition compared to no drug treatment (Met-EMx1) or insulin treatment (Met-EMx1 I) alone. e The average amplitude of sIPSCs is much higher following insulin receptor sensitization with pioglitazone. Box and whisker plots showing the population distribution

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