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Fig. 2 | Molecular Autism

Fig. 2

From: Insulin receptor sensitization restores neocortical excitation/inhibition balance in a mouse model of autism

Fig. 2

Insulin-induced increased inhibition. a–c Example records of GABAA receptor-mediated sIPSCs. HP holding potential. d Cumulative fraction curves of the sIPSC amplitudes show that the amplitude distribution for insulin (WT I) and insulin + pioglitazone (WT I + P) are shifted to the right (larger amplitude), indicating that both conditions increase the amplitude of sIPSCs compared to no drug controls. e The average amplitude of sIPSCs is higher with either drug application condition compared to the controls, but not different between the two drug application conditions. f Box and whisker plots showing the population distribution

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