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Fig. 2 | Molecular Autism

Fig. 2

From: Network-specific sex differentiation of intrinsic brain function in males with autism

Fig. 2

Conjunction analyses. Plots (one per each resting-state fMRI metric [R-fMRI]) show the spatial overlap percentages across 500 successive statistical voxel-level thresholds for the four possible overlap scenarios (turquoise: shift-towards-maleness (STM) ASD-related increases (EMB 1; as indicated by the upward arrow) = ASD♂ > NT♂ and NT♂ > NT♀; blue: STM ASD-related decreases (EMB 2; as indicated by the downward arrow) = ASD♂ < NT♂ and NT♂ < NT♀; orange: shift-towards-femaleness (STF) ASD-related increases (GI 1; as indicated by the upward arrow) = ASD♂ > NT♂ and NT♂ < NT♀; yellow: STF ASD-related decreases (GI 2; as indicated by the downward arrow) = ASD♂ < NT♂ and NT♂ > NT♀). The black solid line represents the median of the null distribution of the random spatial overlap generated by 5000 Monte Carlo simulations for each threshold. The dotted lines mark the 0.5th and 99.5th percentiles of the null distribution of random spatial overlap. Only spatial overlaps consistently above the 99.5th percentile of the null distribution for at least 70% of the 500 tested thresholds were utilized for subsequent results’ characterization. R-fMRI abbreviations: DC degree centrality, fALFF fractional amplitude of low frequency fluctuations, ReHo regional homogeneity, VMHC voxel-mirrored homotopic connectivity, PCC-iFC posterior cingulate cortex intrinsic functional connectivity

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