Table 1 Endpoint behavioural outcomes
Week 12 outcomes | Summary statistics | Mean difference | |||||
|---|---|---|---|---|---|---|---|
| Â | Sample | Placebo | Simvastatin | Adjusted mean difference (95% CI) | Bootstrap SE | Effect size (95% CI) | Number analysed |
ABC | N = 28 | N = 15 | N = 13 |  |  |  |  |
 Irritability | 19.14 (11.62) | 16.40 (10.82) | 22.31 (12.14) | 1.66 (− 4.61, 7.93) | 3.20 | 0.14 (− 0.40, 0.68) | 28 |
 Lethargy* | 12.63 (10.01) | 10.53 (9.61) | 15.25 (10.30)* | 3.60 (− 4.09, 11.28) | 3.92 | 0.29 (− 0.41, 1.13) | 26 |
 Stereotypy | 5.71 (5.08) | 3.93 (3.63) | 7.77 (5.83) | 1.61 (− 0.98, 4.20) | 1.32 | 0.32 (− 0.19, 0.83) | 28 |
 Hyperactivity | 23.61 (13.68) | 19.13 (13.17) | 28.77(12.83) | 3.87 (− 3.28, 11.01) | 3.65 | 0.28 (− 0.24, 0.80) | 28 |
 Inappropriate speech | 5.89 (3.11) | 4.80 (2.54) | 7.15 (3.31) | 1.77 (− 0.10, 3.63) | 0.95 | 0.57 (− 0.03, 1.17) | 28 |
25% reduction irritability subscale | N = 11 | N = 5 | N = 6 |  |  |  |  |
Conners | N = 28 | N = 15 | N = 13 |  |  |  |  |
 Inattention | 77.25 (12.57) | 74.53 (14.16) | 80.38 (10.08) | 5.33 (− 0.96, 11.61) | 3.21 | 0.42 (− 0.08, 0.92) | 27 |
 Hyperactivity | 73.54 (15.92) | 69.40 (17.12) | 78.31 (13.51) | −0.98 (− 8.09, 6.13) | 3.63 | −0.06 (− 0.51, 0.39) | 27 |
 Learning problems | 69.25 (14.62) | 65.40 (12.91) | 73.69 (15.71) | 1.59 (− 2.13, 5.30) | 1.89 | 0.11 (− 0.15, 0.36) | 27 |
 Executive function | 71.82 (14.59) | 68.20 (16.24) | 76.00 (11.66) | 4.04 (− 2.51, 10.59) | 3.34 | 0.28 (− 0.17, 0.73) | 27 |
 Aggression | 70.43 (18.98) | 68.40 (20.86) | 72.77 (17.09) | − 0.05 (− 11.05,10.96) | 5.61 | − 0.00 (− 0.58, 0.58) | 27 |
 Peer relations | 83.89 (11.53) | 82.00 (13.51) | 86.08 (8.73) | 1.38 (− 4.45, 7.21) | 2.97 | 0.12 (− 0.39, 0.63) | 27 |
Parent-defined target symptoms (PDTS) | N = 26 | N = 14 | N = 12 |  |  |  |  |
Mean (SD) | 3.52 (1.77) | 3.75 (1.86) | 3.25 (1.68) | Â | Â | Â | Â |
Responders (PDTS score < 3) | 7 | 2 | 5 |  |  |  |  |
CGI* | N = 26 | N = 14 | N = 12 |  |  |  |  |
 Global improvement Mean (SD) | 3.31 (0.84) | 3.57 (0.85) | 3.00 (0.74) |  |  |  |  |
Treatment responder+ | N = 3 | N = 0 | N = 3 |  |  |  |  |