|
Amino acid
|
Renal clearance (mL/mg creatinine)
| |
|---|
|
Healthy controls
|
ASD
|
P value
|
|---|
|
Ala
|
1.03 (0.746–1.712)
|
1.27 (0.890–1.65)
| |
|
Arg
|
0.011 (0.009–0.015)
|
0.008 (0.006–0.010)
|
0.0019*
|
|
Asn
|
2.80 (2.22–4.76)
|
4.30 (3.05–7.14)
|
0.0055
|
|
Asp
|
3.81 (3.04–4.96)
|
4.73 (2.92–7.82)
| |
|
Cys (total)
|
0.646 (0.518–0.812)
|
0.629 (0.452–1.133)
| |
|
Gln
|
1.18 (0.913–1.53)
|
1.54 (1.14–1.96)
|
0.025
|
|
Glu
|
0.210 (0.158–0.304)
|
0.243 (0.179–0.357
|
0.049
|
|
Gly
|
0.0050 (0.002–0.009)
|
0.0067 (0.004–0.029)
|
0.018
|
|
His
|
0.029 (0.024–0.040)
|
0.040 (0.027–0.053)
| |
|
IIe
|
0.262 (0.192–0.347)
|
0.354 (0.256–0.441)
|
0.0116
|
|
Leu
|
0.358 ± 0.135
|
0.402 ± 0.105
| |
|
Lys
|
0.011 (0.005–0.018)
|
0.0071 (0.005–0.011)
| |
|
Met
|
0.0066 ± 0.0015
|
0.0056 ± 0.0023
| |
|
Phe
|
1.32 (0.959–2.02)
|
1.65 (1.33–1.95)
| |
|
Pro
|
0.077 ± 0.031
|
0.104 ± 0.039
|
0.0138
|
|
Ser
|
3.66 (2.95–4.79)
|
5.22 (3.99–6.78)
|
0.0081
|
|
Thr
|
2.023 ± 0.765
|
2.44 ± 1.05
| |
|
Trp
|
0.209 (0.155–0.242)
|
0.287 (0.166–0.497)
|
0.010
|
|
Tyr
|
0.0209 (0.016–0.025)
|
0.015 (0.012–0.025)
| |
|
Val
|
0.0017 (0.0014–0.0022)
|
0.0016 (0.0013–0.0026)
| |
- Data are mean ± SD or median (lower–upper quartile); healthy controls, n = 21, and ASD, n = 27. Significance: t test for parametric data and Mann-Whitney U for non-parametric data
- *P < 0.05, after Bonferroni correction of 20 applied
