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Table 6 Renal clearance of amino acids

From: Advanced glycation endproducts, dityrosine and arginine transporter dysfunction in autism - a source of biomarkers for clinical diagnosis

Amino acid Renal clearance (mL/mg creatinine)  
Healthy controls ASD P value
Ala 1.03 (0.746–1.712) 1.27 (0.890–1.65)  
Arg 0.011 (0.009–0.015) 0.008 (0.006–0.010) 0.0019*
Asn 2.80 (2.22–4.76) 4.30 (3.05–7.14) 0.0055
Asp 3.81 (3.04–4.96) 4.73 (2.92–7.82)  
Cys (total) 0.646 (0.518–0.812) 0.629 (0.452–1.133)  
Gln 1.18 (0.913–1.53) 1.54 (1.14–1.96) 0.025
Glu 0.210 (0.158–0.304) 0.243 (0.179–0.357 0.049
Gly 0.0050 (0.002–0.009) 0.0067 (0.004–0.029) 0.018
His 0.029 (0.024–0.040) 0.040 (0.027–0.053)  
IIe 0.262 (0.192–0.347) 0.354 (0.256–0.441) 0.0116
Leu 0.358 ± 0.135 0.402 ± 0.105  
Lys 0.011 (0.005–0.018) 0.0071 (0.005–0.011)  
Met 0.0066 ± 0.0015 0.0056 ± 0.0023  
Phe 1.32 (0.959–2.02) 1.65 (1.33–1.95)  
Pro 0.077 ± 0.031 0.104 ± 0.039 0.0138
Ser 3.66 (2.95–4.79) 5.22 (3.99–6.78) 0.0081
Thr 2.023 ± 0.765 2.44 ± 1.05  
Trp 0.209 (0.155–0.242) 0.287 (0.166–0.497) 0.010
Tyr 0.0209 (0.016–0.025) 0.015 (0.012–0.025)  
Val 0.0017 (0.0014–0.0022) 0.0016 (0.0013–0.0026)  
  1. Data are mean ± SD or median (lower–upper quartile); healthy controls, n = 21, and ASD, n = 27. Significance: t test for parametric data and Mann-Whitney U for non-parametric data
  2. *P < 0.05, after Bonferroni correction of 20 applied