Advanced glycation endproducts, dityrosine and arginine transporter dysfunction in autism - a source of biomarkers for clinical diagnosis

Table 5 Renal clearance of glycation, oxidation, and nitration free adducts

Amino acid	Renal clearance (μL/mg creatinine)
Amino acid	Healthy controls	ASD	P value
FL^#	0.696 (0.375–1.16)	0.866 (0.384–2.31)
CML	0.297 (0.249–0.387)	0.259 (0.171–0.782)
CEL	0.0068 (0.003–0.019)	0.0042 (0.002–0.011)
G-H1	21.2 (13.1–34.7)	23.9 (15.0–57.7)
MG-H1^#	0.718 (0.496–1.04)	0.628 (0.363–0.912)
3DG-H	0.067 (0.033–0.163)	0.087 (0.042–0.131)
CMA	1.57 (0.997–2.08)	0.791 (0.465–1.36)	0.0011*
GSP	0.121 (0.083–0.274)	0.112 (0.067–0.195)
MOLD	0.214 (0.075–0.487)	0.269 (0.153–0.656)
Pyrraline	0.81 (0.58–1.17)	1.07 (0.64–1.96)
DT	0.119 (0.657–2.02)	0.747 (0.545–0.107)	0.0025
NFK	0.062 (0.038–0.109)	0.096 (0.049–0.139)	0.030
GSA	29.9 (11.1–45.8)	17.8 (1.96–26.1)
3-NT	0.068 (0.034–0.100)	0.042 (0.036–0.129)

Data are mean ± SD or median (lower–upper quartile); healthy controls, n = 21, and ASD, n = 27. Significance: t-test for parametric data and Mann-Whitney U for non-parametric data
*P < 0.05, after Bonferroni correction of 14 applied
^#mL/mg creatinine

ISSN: 2040-2392