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Table 2 Glycation, oxidation, and nitration adduct residue content of plasma protein

From: Advanced glycation endproducts, dityrosine and arginine transporter dysfunction in autism - a source of biomarkers for clinical diagnosis

Glycation markers Healthy controls ASD P value
FL (mmol/mol lys) 1.27 ± 0.39 1.41 ± 0.53 NS
CML (mmol/mol lys) 0.158 ± 0.026 0.190 ± 0.038 0.0018*
CEL (mmol/mol lys) 0.117 ± 0.044 0.092 ± 0.054 NS
G-H1 (mmol/mol arg) 0.012 ± 0.005 0.016 ± 0.011 NS
MG-H1 (mmol/mol arg) 0.473 ± 0.074 0.535 ± 0.100 0.021
3DG-H (mmol/mol arg) 0.165 ± 0.037 0.138 ± 0.027 0.0052
CMA (mmol/mol arg) 0.054 (0.043–0.067) 0.077 (0.066–0.101) 0.000082**
MOLD (mmol/mol lys) 0.027 ± 0.011 0.025 ± 0.016 NS
GSP (mmol/mol lys) 0.514 ± 0.111 0.571 ± 0.206 NS
DT (mmol/mol tyr) 0.025 (0.019–0.031) 0.047 (0.035–0.094) 0.000012***
NFK (mmol/mol trp) 15.6 ± 1.7 15.0 ± 1.5 NS
AASA (mmol/mol lys) 0.154 ± 0.048 0.152 ± 0.081 NS
GSA (mmol/mol arg) 0.639 ± 0.327 0.713 ± 0.350 NS
3-NT (mmol/mol tyr) 0.0056 (0.0045–0.0069) 0.0053 (0.0045–0.0064) NS
  1. Data are median (lower–upper quartile); healthy controls, n = 21, and ASD, n = 27. Significance (Mann–Whitney U)
  2. *P < 0.05, **P < 0.01, and ***P < 0.001 after Bonferroni correction of 14 applied