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Table 3 Significance analysis of interaction effects in cytokine levels and clinical covariates

From: Cytokine levels and associations with symptom severity in male and female children with autism spectrum disorder

  Combined sex Males Females
Effect Chisq Df Pr(>Chisq) Chisq Df Pr(>Chisq) Chisq Df Pr(>Chisq)
(Intercept) 387.78 1 < 0.001 239.73 1 < 0.001 105.51 1 < 0.001
Severity 3.28 1 0.07 1.48 1 0.22 0.88 1 0.35
Age 0.01 1 0.91 0.12 1 0.73 0.44 1 0.51
SRS 0.13 1 0.72 0.06 1 0.81 1.35 1 0.25
Sleep 0.08 1 0.78 0.23 1 0.63 0.38 1 0.54
GI 0.53 1 0.47 0.96 1 0.33 0.25 1 0.62
Analyte 1079.27 26 < 0.001 787.12 26 < 0.001 247.60 26 < 0.001
Severity:analyte 43.64 26 0.02 16.42 26 0.93 71.10 26 < 0.001
Age:analyte 75.23 26 < 0.001 60.36 26 < 0.001 41.61 26 0.03
SRS:analyte 10.96 26 1.00 19.09 26 0.83 40.28 26 0.04
Sleep:analyte 17.09 26 0.91 12.47 26 0.99 28.20 26 0.35
GI:analyte 9.65 26 1.00 13.11 26 0.98 23.97 26 0.58
  1. Analysis of deviance tables (type III Wald chi-square tests) for the statistical model: mY~(severity + age + sex + SRS + sleep + GI)*Analyte + (1|ID). Where mY represents the normalized log2 of the fluorescence responses with respect to run (Additional file 1: Figure S2)