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Fig. 4 | Molecular Autism

Fig. 4

From: RNA sequencing and proteomics approaches reveal novel deficits in the cortex of Mecp2-deficient mice, a model for Rett syndrome

Fig. 4

Transcriptome-proteome expression correlation in Mecp2 Jae/y cortex. a. Overall gene-protein expression correlation. Detected genes (7026) from the RNA-Seq data set were matched against detected proteins (4789) from the proteomics data set, resulting in a total of 3780 gene-protein matches. Each individual gene-protein match is plotted by gene fold change expression (x-axis, Mecp2 Jae/y/WT) and its corresponding protein fold change expression (y-axis, Mecp2 Jae/y/WT). Pearson’s R reports a correlation of 0.12. b. Significant gene and significant protein expression correlation. Out of the 3780 detected gene-protein matches, only 35 have both a significant gene (q < 0.05) and corresponding significant protein (p < 0.1) match. Each match is plotted by gene fold change expression (x-axis, Mecp2 Jae/y/WT) and its corresponding protein fold change expression (y-axis, Mecp2 Jae/y/WT). Pearson’s R reports a correlation of 0.74

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Molecular Autism

ISSN: 2040-2392