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Table 5 Quantitative phenotype and group differences between DYRK1A, idiopathic, and CHD8 groups

From: Clinical phenotype of ASD-associated DYRK1A haploinsufficiency

  DYRK1A (UW-SNV) SSC idiopathic subset CHD8 t statistics DYRK1A vs SSC t statistics DYRK1A vs CHD8 t statistics CHD8 vs SSC
Phenotypic characteristic Mean SD N Mean SD N Mean SD N t d t d t d
Head circumference Z score − 3.62 2.17 10 1.21 0.39 10 1.76 2.9 11 6.94* 3.10 6.49** 2.84 NS
Full-scale IQ 45.30 18.14 10 81.20 26.12 10 60.91 27.39 11 3.57* 1.60 NS NS
Overall adaptive functioning 54.80 9.04 10 70.50 9.40 10 65.00 18.49 12 3.81* 1.70 NS NS
Autism severity (ADOS CSS) 6.50 2.80 10 7.70 1.25 10 8.18 1.78 11 NS NS NS
Age walked unaided 19.70 5.64 10 13.22 2.59 10 18.50 4.38 12 NS NS NS
Age of first single words 45.14 22.82 7 17.50 7.92 10 25.17 28.01 12 NS NS NS
  1. Descriptives for phenotypic variables commonly impaired in DYRK1A haploinsufficiency for three groups: DYRK1A (n = 10), SSC idiopathic subset randomly samples and matched on age and gender (n = 10), and CHD8 (n = 12). Group comparisons using independent sample t tests between (1) DYRK1A and SSC groups, (2) DYRK1A and CHD8 groups, and (3) CHD8 and SSC groups. *Significant differences between DYRK1A and idiopathic groups, p < 0.002; **Significant differences between DYRK1A and CHD8 groups, p < 0.001. Independent sample t and Cohen’s d values provided when significant, p value adjusted for multiple comparisons, NS not significant