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Table 4 Neurological findings in individuals with FOXP1 syndrome

From: Prospective investigation of FOXP1 syndrome

Neurological feature S1 S2 S3 S4 S5 W1 W2 W3 W4 Total (%)
Brain imaging abnormality + a + b + c + d n/a n/a + e + f 6/7 (86%)
EEG abnormality n/a n/a n/a n/a + n/a + 2/4 (50%)
Hypotonia + + + + + + + + 8/9 (89%)
Feeding issues (past/present) + + + 3/9 (33%)
Dysarthria + + + + + + + + + 9/9 (100%)
Gait abnormalities + + + + + + + 7/9 (78%)
Fine/gross motor coordination deficit + + + + + + + + + 9/9 (100%)
Hypoacusis/hearing loss + 1/9 (11%)
Spinal cord malformation +g 1/9 (11%)
  1. aMildly dilated lateral ventricles
  2. bNon-enhancing subcortical and deep white matter abnormalities; incidental finding of venous angioma in left frontal lobe
  3. cProminent Virchow-Robin spaces. Small partial cavum septum pellucidum anteriorly
  4. dMild diffuse periventricular leukomalacia
  5. eArachnoid cysts (cerebellum, left hemisphere); enlarged ventricles
  6. fEnlarged ventricles
  7. gTethered cord and conus medullaris terminating at the lumbar spine segment L3
  8. n/a information not available