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Table 2 Neuropsychological and psychiatric manifestations in individuals with FOXP1 syndrome

From: Prospective investigation of FOXP1 syndrome

Neuropsychological assessments S1 S2 S3 S4 S5 W1 W2 W3 W4 Total(%)/Average
Age (months) 71 200 133 138 96 191 134 118 117 133.1
ASD symptoms
 ASD on ADOS-2a + ++ ++ ++ n/a 4/8 (50%)
 ADOS-2 Comparison Score 3 5 7 3 3 10 1 6 n/a 4.8
 ASD on ADI-R + + + + 4/9 (44%)
 Consensus diagnosis of ASD + + n/a 2/8 (25%)
Cognitive functioning (SS)
 Nonverbal IQ 95 44 56 61 73 19 59 31 70 56.4
 Verbal IQ 92 44 51 59 58 15 40 24 74 50.8
 Full scale IQ 93 42 51 59 64 17 52 29 68 52.8
Adaptive behavior (SS)
 Vineland-II communication 81 59 69 67 74 42 61 57 67 64.1
 Vineland-II daily Living 64 47 58 58 78 38 52 62 66 58.1
 Vineland-II socialization 74 54 64 69 83 42 68 55 69 64.2
 Vineland-II composite 69 53 62 63 77 39 59 59 67 60.9
Language (AE in months)
 Expressive vocabularyb 55 78 94 95 59 n/a 81 35 n/a 71.0
 Receptive vocabularyc 56 69 75 93 54 44 81 29 n/a 62.6
 Vineland-II expressive 42 48 59 54 55 25 52 23 46 44.9
 Vineland-II receptive 41 35 47 47 30 34 26 34 30 36.0
Motor skills
 Visual-motor integration (SS)d 78 45 <45 45 70 n/a 47 <45 n/a < 53.6
 Vineland-II gross motor (AE) 46 n/a 47 82 59 n/a n/a 37 n/a 54.2
 Vineland-II fine motor (AE) 34 n/a 69 66 68 n/a n/a 36 n/a 54.6
Psychiatric features
 Anxiety + + + + + + + + 8/9 (89%)
 Compulsive behaviors + + + + + + + + + 9/9 (100%)
 Attention problems + + + + + + + + + 9/9 (100%)
 Externalizing symptoms + + + + + + + + + 9/9 (100%)
  1. aADOS-2 classification: + = autism spectrum; ++ = autism
  2. bExpressive vocabulary measured by the Expressive Vocabulary Test, 2nd Edition
  3. cReceptive vocabulary measured by the Peabody Picture Vocabulary Test, 4th Edition
  4. dVisual-motor integration measured by the Test of Visual-Motor Integration, 6th Edition
  5. ADI-R Autism Diagnostic Interview-Revised, ADOS-2 Autism Diagnostic Observation Schedule, 2nd Edition, AE age equivalents, SS standard score, n/a information not available