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Fig. 6 | Molecular Autism

Fig. 6

From: Zebrafish knockout of Down syndrome gene, DYRK1A, shows social impairments relevant to autism

Fig. 6

dyrk1aa KO zebrafish show impaired social behavior in the shoaling assay. a Schematic description of the “mini shoal” formed at the ridge of water body in a flat and round bowl. bf Snapshots of shoaling behavior in a group of WT fish, ranging from three to seven fish/group. In most cases, the WT fish group showed “social cohesion” moving together along the narrow space of “mini shoal” in the round bowl. g A snapshot of group behavior during the shoaling assay. Three fish were used as a group in this assay. Arrows indicate individual adult fish. h Mean distance between individuals (cm) was used to show the degree of social cohesion. The dyrk1aa KO fish group showed “loosened” social cohesion, compared to WT fish. Number of trials for this experiment: n = 10. Data are presented as mean ± SEM. *** p < 0.001 by Student’s t test

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