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Fig. 3 | Molecular Autism

Fig. 3

From: Testing the excitation/inhibition imbalance hypothesis in a mouse model of the autism spectrum disorder: in vivo neurospectroscopy and molecular evidence for regional phenotypes

Fig. 3

Nf1 +/− mutation induced regional changes in GABA(A) α1 subunit receptor pattern. GABA(A) receptor immunoreactivity (red; Hoescht 33342—blue) was altered in Nf1 +/− mice hippocampus, prefrontal cortex, and striatum, with substantial hippocampal increases, independently confirming the results shown in Fig. 2, and with reductions in the other regions, with a patchy pattern in the striatum (with both hypodense and hyperdense regions) (a). Accordingly, quantification of respective fluorescence intensity (b) demonstrated that the NF1 induced significant GABA(A) receptor augmentation in hippocampus while prefrontal cortex and striatum showed a downregulation. Data are expressed as mean ± SEM (n = 8–14). * p < 0.05, *** p < 0.001, statistical significance comparing with respectively wild-type using the Mann-Whitney’s test. Scale bar, 20 μm

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