Replicative genetic association study between functional polymorphisms in AVPR1A and social behavior scales of autism spectrum disorder in the Korean population

Table 3 Family-based association results of polymorphisms in AVPR1A with single quantitative trait by additive model

Traits			SCQ	ASDS	SRS	K-CBCL	ADIR-A1	ADIR-A2	ADIR-A3	ADIR-A4	ADIR-total	VABS
Marker	Freq.	N	p	p	p	p	p	p	p	p	p	p
rs7294536 G	0.193	71	0.049	0.019	0.033	0.015	0.016	0.029	0.030	0.019	0.021	0.407
rs7294536 A	0.807	71	0.049	0.019	0.033	0.015	0.016	0.029	0.030	0.019	0.021	0.407
rs10877969 G	0.089	47	0.001	< 0.001	< 0.001	< 0.001	0.001	0.001	0.001	0.002	0.001	< 0.001
rs10877969 A	0.911	47	0.001	< 0.001	< 0.001	< 0.001	0.001	0.001	0.001	0.002	0.001	< 0.001

Freq. allele frequency, N number of informative nuclear families, p p value, SCQ Social Communication Questionnaires, ASDS Asperger Syndrome Diagnostic Scale, SRS social responsiveness scale, K-CBCL Korean Child behavior checklist (social problems), K-ADIR Autism Diagnostic Interview-Revised, ADI-A1 failure to use nonverbal behaviors to regulate social interaction, ADI-A2 failure to develop peer relationship, ADI-A3 lack of shared enjoyment, ADI-A4 lack of socioemotional reciprocity, VABS Vineland Adaptive Behavior Scales

ISSN: 2040-2392