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Fig. 6 | Molecular Autism

Fig. 6

From: Prenatal levonorgestrel exposure induces autism-like behavior in offspring through ERβ suppression in the amygdala

Fig. 6

Overexpression of ERβ in the amygdala restores prenatal levonorgestrel exposure-induced autism-like behavior in 10-week-old offspring, while ERβ knockdown mimics the effect. The 8-week-old male offspring from the VEH group received either empty control (VEH/EMP) or ERβ knockdown (VEH/shERβ) lentivirus infusion, and the male offspring from the LNG group received either empty control (LNG/EMP) or ERβ expression (LNG/↑ERβ) lentivirus infusion. At 10 weeks of age, the offspring were used for autism-like behavior testing. a Buried marbles tests, n = 8. b Interaction time, n = 8. c, d Time spent in c open and d closed arms in the EPM test, n = 9. eg Time spent in e central and f peripheral area and g locomotor activity in the open-field test, n = 9. *P < 0.05 vs. VEH group. Results are expressed as mean ± SEM

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