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Table 1 Significantly changed proteins identified by label-based LC-SRM in the frontal cortex and hippocampus of Tsc1 +/− mice compared to wildtype mice

From: A brain proteomic investigation of rapamycin effects in the Tsc1 +/− mouse model

  1. The first stage of the analysis consisted of a global profiling approach, followed by validation with a specific and sensitive label-based assay panel. p values were determined using SRMstats (linear model with fixed subject effects) and corrected (p*) to control for multiple hypothesis testing (Benjamini-Hochberg) [90]. For reasons of clarity, only ratios and significance levels of significantly changing proteins are shown. For full information, see Additional file 3. n.s. not significant, n.d. not detected. Validated findings are in gray shading