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Table 1 Differentially expressed miRNAs, which are associated with psychiatric disorders [13], between VPA- and saline-exposed embryos in the whole brain

From: Prenatal exposure to valproic acid increases miR-132 levels in the mouse embryonic brain

Name

log2 Ratio (VPA/Sal)

FDR

mmu-miR-15a-5p

1.76

1.86E–05

mmu-miR-15b-5p

−3.20

2.41E–41

mmu-miR-16-2-3p

−1.85

7.20E–163

mmu-miR-23b-5p

−1.30

2.75E–04

mmu-miR-24-3p

−1.29

6.11E–134

mmu-miR-30e-5p

2.55

Nearly zero

mmu-miR-34a-3p

9.68

9.53E–04

mmu-miR-92b-5p

−1.12

Nearly zero

mmu-miR-93-3p

1.34

4.00E–134

mmu-miR-96-5p

4.94

1.17E–170

mmu-miR-132-5p

1.31

3.50E–06

mmu-miR-146a-5p

1.95

2.18E–63

mmu-miR-146b-3p

−1.26

Nearly zero

mmu-miR-152-3p

1.45

Nearly zero

mmu-miR-181c-5p

−1.05

8.13E–08

mmu-miR-219a-2-3p

1.02

1.53E–276

mmu-miR-346-3p

−1.31

4.94E–12

mmu-miR-363-5p

−2.09

2.88E–29

mmu-miR-455-5p

−2.72

3.06E–238

mmu-miR-494-3p

1.04

6.20E–55

  1. Pregnant mice were treated with VPA (500 mg/kg, i.p.) or saline on gestation days 12.5. At 12 h after the drug exposure, the whole brains were immediately removed from male embryos, total RNA was extracted, and then miRNA expression was analyzed by RNA sequencing (n = 3 from two VPA- and two saline-treated dams)